Baculoviral IAP Repeat-Containing 5 (BIRC5) (C-Term) antibody

Details for Product No. ABIN115387
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms API4, EPR-1, AAC-11, Api4, TIAP, survivin40, AP14
Epitope
C-Term
(21), (5), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(70), (26), (9), (1), (1), (1), (1)
Host
Rabbit
(68), (18), (2)
Clonality
Polyclonal
Application
Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(72), (30), (24), (14), (14), (12), (8), (6), (6), (5), (4), (3), (1), (1), (1)
Pubmed 3 references available
Quantity 0.5 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN115387
434.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide derived from the C-terminal region of Survivin.
Specificity This antibody reacts with a 16.5 kDa protein, known as Survivin.
Cellular Localization: Cytoplasmic
Purification Purified
Alternative Name IAP4 / BIRC5
Background Survivin is an inhibitor of apoptosis protein. It is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle. Disruption of survivin-microtubule interactions results in loss of survivins antiapoptosis function and increased Caspase-3 activity.Synonyms: API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, Baculoviral IAP repeat-containing protein 5, Survivin
Gene ID 332
NCBI Accession NP_001012270
UniProt O15392
Research Area Cancer, Apoptosis/Necrosis, Neurology
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer 10 mM citrate buffer, pH 6.0, Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Ambrosini, Adida, Altieri: "A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma." in: Nature medicine, Vol. 3, Issue 8, pp. 917-21, 1997 (PubMed).

Li, Ambrosini, Chu et al.: "Control of apoptosis and mitotic spindle checkpoint by survivin." in: Nature, Vol. 396, Issue 6711, pp. 580-4, 1999 (PubMed).

General Lu, Altieri, Tanigawa: "Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas." in: Cancer research, Vol. 58, Issue 9, pp. 1808-12, 1998 (PubMed).

Validation Images
Did you look for something else?
back to top