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X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3) (N-Term) antibody

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(9), (8), (7), (6), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
(86), (13), (3), (1)
(72), (16), (5)
(1), (1), (1), (1)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(73), (25), (24), (15), (8), (5), (3), (1), (1), (1), (1), (1)
Pubmed 3 references available
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Quantity 1 mL
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Immunogen A synthetic peptide derived from the N-terminus of human XRCC3 protein.
Specificity This antibody reacts with a 32 kDa protein, known as XRCC3 (X-Ray Cross Complementing 3).
Cellular Localization: Nuclear, cytoplasmic
Purification Purified
Alternative Name XRCC3 (XRCC3 Antibody Abstract)
Background XRCC3 is essential for repairing the double strand DNA breaks by homologous recombination between sister chromatids. It is homologous to Rad1. Five human homologues of RAD 51, XRCC2, XRCC3, RAD51B, RAD51C, RAD51D, interact among themselves to form one big complex or several smaller complexes.Synonyms: DNA repair protein XRCC3, X-ray repair cross-complementing protein 3
Gene ID 7517
NCBI Accession NP_001093588
UniProt O43542
Research Area Chromatin and Nuclear Signaling, Chromatin Binding Proteins, DNA/RNA
Pathways DNA Damage Repair
Application Notes Western Blot: 1: 100-500. Immunohistochemistry on paraffin embedded sections: diluted of 1: 25-1: 50 in an ABC method (30 minutes at room temperature)Recommended Positive Control: Testis
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 10 mM citrate buffer, pH 6.0 - containing sodium azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3) (N-Term) antibody (ABIN115394) Western blot analysis of human lung cell extract with XRCC3 antibody. ABIN115394
Background publications Bramhall, Neoptolemos, Stamp et al.: "Imbalance of expression of matrix metalloproteinases (MMPs) and tissue inhibitors of the matrix metalloproteinases (TIMPs) in human pancreatic carcinoma." in: The Journal of pathology, Vol. 182, Issue 3, pp. 347-55, 1997 (PubMed).

Windsor, Steele, LeBlanc et al.: "Catalytic domain comparisons of human fibroblast-type collagenase, stromelysin-1, and matrilysin." in: Biochimica et biophysica acta, Vol. 1334, Issue 2-3, pp. 261-72, 1997 (PubMed).

Knox, Boreham, Walker et al.: "Mapping of the metalloproteinase gene matrilysin (MMP7) to human chromosome 11q21-->q22." in: Cytogenetics and cell genetics, Vol. 72, Issue 2-3, pp. 179-82, 1997 (PubMed).

Catalog No. ABIN115394

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