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alpha-Methylacyl-CoA Racemase (AMACR) antibody

Details for Product No. ABIN115448
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Antigen
Synonyms AMACR, DKFZp469O1232, amacr, NCU04099.1, MGC89832, AMACRD, CBAS4, RACE, RM, Macr1, Da1-8, Marc1
Reactivity
Human
(86), (27), (24)
Host
Rabbit
(69), (18)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(56), (30), (28), (28), (12), (10), (9), (7), (7), (2), (2)
Pubmed 1 reference available
Quantity 0.5 mL
Shipping to United States (Change)
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The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN115448
335.50 $
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Immunogen A synthetic human AMACR peptide.
Specificity Reacts to P504S Alpha-Methylacyl-CoA Racemace. Cellular Localization: Cytoplasmic.
Purification Purified
Alternative Name AMACR / RACE
Background P504S (AMARC) has been recently described as prostate cancer-specific gene that encodes a protein involved in the beta-oxidation of branched chain fatty acids. Expression of P504S protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. It stains premalignant lesions of prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. P504S can be used as a positive marker for PIN.
Alternate names: 2-methylacyl-CoA racemase, Alpha-methylacyl-CoA racemase, P504S
Gene ID 23600
NCBI Accession NP_055139.4
UniProt Q9UHK6
Application Notes Immunohistochemistry on Formalin-Fixed Paraffin Embedded Sections: 1/25-1/50 in anABC method (30 minutes at room temperature). Formalin fixed paraffin embedded tissue sections require high temperature antigenunmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Recommended Positive Control: Prostate carcinoma. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-alpha-Methylacyl-CoA Racemase (AMACR) antibody Formalin fixed paraffin embedded human tonsil stained with P504S antibody. ABIN115447
Background publications Beach, Gown, De Peralta-Venturina et al.: "P504S immunohistochemical detection in 405 prostatic specimens including 376 18-gauge needle biopsies." in: The American journal of surgical pathology, Vol. 26, Issue 12, pp. 1588-96, 2002 (PubMed).

Validation Images
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