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Secretoglobin, Family 1A, Member 1 (Uteroglobin) (SCGB1A1) antibody

Details for Product No. ABIN115502
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Antigen
Synonyms SCGB1A1, CC10, CC16, CCPBP, CCSP, UGB, UP-1, UP1, PCB-BP, UG, Utg, PCBB, Ugb, UGL
Reactivity
Human
(45), (33), (31)
Host
Rabbit
(61), (17), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), ELISA, Western Blotting (WB)
(41), (30), (23), (22), (18), (8), (6), (3), (2), (1), (1), (1)
Pubmed 8 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN115502
533.50 $
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Immunogen Recombinant human CC16 produced in E. coli.
Specificity This antibody reacts to Clara Cell Protein.
Purification Immunoaffinity chromatography
Alternative Name SCGB1A1 / Uteroglobin
Background Human Clara Cell Protein (CC16, CC10 and also called uteroglobin, urinary protein 1 or Clara Cell Secretory Protein) belongs to the family of secretoglobins and is a secreted protein product of non-ciliated bronchiolar Clara cells. Its function remains to be elucidated but there is convincing data suggesting its phospholipase A2 inhibitory activity as well as a number of other immunomodulatory features including inhibition of interferon gamma signaling and Th1 vs. Th2 lymphocyte regulation. It was proposed as a potential peripheral marker of respiratory epithelial injury and bronchial dysfunction. In serum, its increase is associated with age, asbestos, nitrogen chloride and ozone exposure, sarcoidosis and high PEEP ventilation. Decreased serum CC16 levels are found after pulmonary resection, in silica-exposed workers, smokers and in asthma. Decreased CC16 concentrations were also found in the amniotic fluid of fetuses suffering from pulmonary hypoplasia caused by various mechanisms (diaphragmatic hernia, diabetic fetopathy, Turner and Down syndrome).
Alternate names: CC10, CCPBP, CCSP, Clara cell phospholipid-binding protein, Secretoglobin family 1A member 1, UGB, UP1, Urinary protein 1
Gene ID 7356
NCBI Accession NP_003348
UniProt P11684
Application Notes ELISA. Western Blot. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore with 0.1 mL of deionized water
Concentration 1.0 mg/mL
Buffer 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2. AZIDE FREE.
Preservative Azide free
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Prior to reconstitution store at -70°C. Following reconstitution store the antibody (in aliquots) at -20°C for 6 months without detectable loss of activity.
Expiry Date 6 months
Background publications Rau, Dimmler, Häfner et al.: "Aberrant expression of TTF-1 and forkhead factor HFH-4 in atrophic gastritis and ciliated metaplasia suggests gastric broncho-pulmonary transdetermination." in: The Journal of pathology, Vol. 206, Issue 4, pp. 383-7, 2005 (PubMed).

Coppens, Van Winkle, Pinkerton et al.: "Distribution of Clara cell secretory protein expression in the tracheobronchial airways of rhesus monkeys." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 292, Issue 5, pp. L1155-62, 2007 (PubMed).

General Bernard, Roels, Lauwerys et al.: "Human urinary protein 1: evidence for identity with the Clara cell protein and occurrence in respiratory tract and urogenital secretions." in: Clinica chimica acta; international journal of clinical chemistry, Vol. 207, Issue 3, pp. 239-49, 1992 (PubMed).

Jackson, Turner, Keen et al.: "Purification and partial amino acid sequence of human urine protein 1. Evidence for homology with rabbit uteroglobin." in: Journal of chromatography, Vol. 452, pp. 359-67, 1989 (PubMed).

Linnoila, Szabo, DeMayo et al.: "The role of CC10 in pulmonary carcinogenesis: from a marker to tumor suppression." in: Annals of the New York Academy of Sciences, Vol. 923, pp. 249-67, 2001 (PubMed).

Shijubo, Itoh, Yamaguchi et al.: "Development of an enzyme-linked immunosorbent assay for Clara cell 10-kDa protein: in pursuit of clinical significance of sera in patients with asthma and sarcoidosis." in: Annals of the New York Academy of Sciences, Vol. 923, pp. 268-79, 2001 (PubMed).

Broeckaert, Clippe, Knoops et al.: "Clara cell secretory protein (CC16): features as a peripheral lung biomarker." in: Annals of the New York Academy of Sciences, Vol. 923, pp. 68-77, 2001 (PubMed).

Nord, Schubert, Cassel et al.: "Decreased serum and bronchoalveolar lavage levels of Clara cell secretory protein (CC16) is associated with bronchiolitis obliterans syndrome and airway neutrophilia in lung transplant recipients." in: Transplantation, Vol. 73, Issue 8, pp. 1264-9, 2002 (PubMed).

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