Secretoglobin, Family 1A, Member 1 (Uteroglobin) (SCGB1A1) antibody

Antigen: Secretoglobin, Family 1A, Member 1 (Uteroglobin) (SCGB1A1)

Synonyms: UGL, SCGB1A1, UGB, CC10, CC16, CCSP

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), ELISA, Western Blotting (WB)

Catalog no.: ABIN115502

Additional Information

Alternative name: SCGB1A1 / Uteroglobin

Gene ID: 7356

UniProt: P11684

Immunogen: Recombinant human CC16 produced in E. coli.

Cross-Reactivity: Human

Description: Human Clara Cell Protein (CC16, CC10 and also called uteroglobin, urinary protein 1 or ClaraCell Secretory Protein) belongs to the family of secretoglobins and is a secreted proteinproduct of non-ciliated bronchiolar Clara cells. Its function remains to be elucidated butthere is convincing data suggesting its phospholipase A2 inhibitory activity as well as anumber of other immunomodulatory features including inhibition of interferon gammasignaling and Th1 vs. Th2 lymphocyte regulation. It was proposed as a potential peripheralmarker of respiratory epithelial injury and bronchial dysfunction. In serum, its increase isassociated with age, asbestos, nitrogen chloride and ozone exposure, sarcoidosis andhigh PEEP ventilation. Decreased serum CC16 levels are found after pulmonary resection, insilica-exposed workers, smokers and in asthma. Decreased CC16 concentrations were alsofound in the amniotic fluid of fetuses suffering from pulmonary hypoplasia caused byvarious mechanisms (diaphragmatic hernia, diabetic fetopathy, Turner and Downsyndrome).

Characteristics: Synonyms: CCPBP, CC10, CCSP, UGB, UP1, Secretoglobin family 1A member 1, Clara cellphospholipid-binding protein, Urinary protein 1

Application Details

Application Notes: ELISA. Western Blot. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 1.0 mg/ml

Purification: Affinity Purified

Buffer: 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2. AZIDE FREE.Reconstitution: Restore with 0.1 ml of deionized water

Storage: Store lyophilized (preferably in a desiccator) at -20°C and in aliquots at -80°C. Reconstituted antibody can be stored at 4°C for a limited period of time, it does not showdecline in activity after two weeks at 4°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Restrictions: For Research Use only

Publications

Bernard, Roels, Lauwerys et al.: "Human urinary protein 1: evidence for identity with the Clara cell protein and occurrence in respiratory tract and urogenital secretions." in: Clinica chimica acta; international journal of clinical chemistry, Vol. 207, Issue 3, pp. 239-49, 1992 (PubMed).

Jackson, Turner, Keen et al.: "Purification and partial amino acid sequence of human urine protein 1. Evidence for homology with rabbit uteroglobin." in: Journal of chromatography, Vol. 452, pp. 359-67, 1989 (PubMed).

Linnoila, Szabo, DeMayo et al.: "The role of CC10 in pulmonary carcinogenesis: from a marker to tumor suppression." in: Annals of the New York Academy of Sciences, Vol. 923, pp. 249-67, 2001 (PubMed).

Shijubo, Itoh, Yamaguchi et al.: "Development of an enzyme-linked immunosorbent assay for Clara cell 10-kDa protein: in pursuit of clinical significance of sera in patients with asthma and sarcoidosis." in: Annals of the New York Academy of Sciences, Vol. 923, pp. 268-79, 2001 (PubMed).

Broeckaert, Clippe, Knoops et al.: "Clara cell secretory protein (CC16): features as a peripheral lung biomarker." in: Annals of the New York Academy of Sciences, Vol. 923, pp. 68-77, 2001 (PubMed).

Nord, Schubert, Cassel et al.: "Decreased serum and bronchoalveolar lavage levels of Clara cell secretory protein (CC16) is associated with bronchiolitis obliterans syndrome and airway neutrophilia in lung transplant recipients." in: Transplantation, Vol. 73, Issue 8, pp. 1264-9, 2002 (PubMed).