Fetuin A antibody (alpha-2-HS-Glycoprotein)

Details for Product anti-AHSG Antibody No. ABIN115504, Supplier: Log in to see
Antigen
  • ahs
  • a2hs
  • hsga
  • fetua
  • wu:fb63g02
  • zgc:103687
  • AHSG
  • MGC116429
  • A2HS
  • AHS
  • FETUA
  • HSGA
  • Aa2-066
  • pp63
  • alpha-2-HS-glycoprotein
  • FETUIN protein
  • Cphamn1_1981
  • AHSG
  • ahsg
  • Ahsg
  • FETUIN
Reactivity
Human
167
53
29
7
2
2
2
1
1
Host
Rabbit
127
25
24
18
15
3
Clonality
Polyclonal
Conjugate
This Fetuin A antibody is un-conjugated
15
13
8
6
6
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
150
102
60
33
31
25
19
16
13
10
6
2
2
1
1
1
1
1
1
Options
Supplier
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Immunogen Human serum
Specificity This antibody reacts to Fetuin-A.
Purification Immunoaffinity chromatography
Alternative Name alpha-2-HS-Glycoprotein (AHSG Antibody Abstract)
Background Fetuin-A (AHSG), a 59 kDa glycoprotein, consisting of two cystatin-like domains and a smaller unrelated domain, is predominantly sinthetized in liver . It is secreted into the blood stream and deposited as a noncollagenous protein in mineralized bones and teeth. Fetuin-A occurs in high serum concentrations during foetal life, whereas its level declines following infection, inflamatory and malignancy. Fetuin-A acts as an important circulating inhibitor of ectopic calcification, frequent complication of many degenerative diseases. Low serum level of Fetuin-A is associated with vascular and valvular calcification, atherosclerosis, malnutrition and higher cardiovascular mortality in chronic renal failure, liver cancer and liver cirrhosis patients on long-term dialysis. AHSG protein represents a natural inhibitor of tyrosinase kinase activity of the insulin receptor. It may play a significant role in regulating postprandial glucose disposal, insulin sensitivity, weight gain, and fat accumulation. The serum and bone-resident Fetuin-A binds to transforming growth factor- beta and blocks TGFbeta binding to cell surface receptors.Synonyms: AHSG, Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, FETUA, Fetuin A, PRO2743
Gene ID 197
NCBI Accession NP_001613
UniProt P02765
Research Area Immunology, Inflammation, Serum/Plasma Proteins
Application Notes ELISA. Western Blot. Immunohistochemistry on frozen sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with 0.1 mL of deionized water
Concentration 1.0 mg/mL
Buffer 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2. AZIDE FREE
Preservative Azide free
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 months.
Expiry Date 6 months
Background publications Ketteler, Gross, Ritz: "Calcification and cardiovascular problems in renal failure." in: Kidney international. Supplement, Issue 94, pp. S120-7, 2005 (PubMed).

Jersmann, Dransfield, Hart: "Fetuin/alpha2-HS glycoprotein enhances phagocytosis of apoptotic cells and macropinocytosis by human macrophages." in: Clinical science (London, England : 1979), Vol. 105, Issue 3, pp. 273-8, 2003 (PubMed).

Schafer, Heiss, Schwarz, Westenfeld, Ketteler, Floege, Muller-Esterl, Schinke, Jahnen-Dechent: "The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification." in: The Journal of clinical investigation, Vol. 112, Issue 3, pp. 357-66, 2003 (PubMed).

Ketteler, Bongartz, Westenfeld, Wildberger, Mahnken, Böhm, Metzger, Wanner, Jahnen-Dechent, Floege: "Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study." in: Lancet, Vol. 361, Issue 9360, pp. 827-33, 2003 (PubMed).

Denecke, Gräber, Schäfer, Heiss, Wöltje, Jahnen-Dechent: "Tissue distribution and activity testing suggest a similar but not identical function of fetuin-B and fetuin-A." in: The Biochemical journal, Vol. 376, Issue Pt 1, pp. 135-45, 2003 (PubMed).

Arnaud, Kalabay: "Alpha2-HS glycoprotein: a protein in search of a function." in: Diabetes/metabolism research and reviews, Vol. 18, Issue 4, pp. 311-4, 2002 (PubMed).

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