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LYVE1 antibody (AA 24-227)

LYVE1 Reactivity: Mouse WB, FACS, IHC (p), IF, IHC (fro), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN115689
  • Target See all LYVE1 Antibodies
    LYVE1 (Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1))
    Binding Specificity
    • 13
    • 12
    • 9
    • 9
    • 8
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 24-227
    Reactivity
    • 76
    • 56
    • 19
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Mouse
    Host
    • 83
    • 6
    • 4
    • 1
    • 1
    • 1
    Rabbit
    Clonality
    • 84
    • 12
    Polyclonal
    Conjugate
    • 52
    • 11
    • 7
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This LYVE1 antibody is un-conjugated
    Application
    • 84
    • 40
    • 38
    • 20
    • 17
    • 9
    • 9
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)
    Specificity
    Highly specifc for Mouse Lyve-1. No cross reactivities observed so far.
    Cross-Reactivity (Details)
    Species reactivity (tested):Mouse.
    Purification
    Antigen Affinity Chromatography
    Immunogen
    Highly pure recombinant Mouse soluble LYVE-1 produced in insect cells (Cat.-No DA3524) Remarks: The recombinant soluble LYVE-1 consists of amino acid 24 (Ala) to 228 (Gly) and is fused to a C-terminal His-tag (6xHis).
    Top Product
    Discover our top product LYVE1 Primary Antibody
  • Application Notes
    ELISA (1-15 μg/mL). Western blot (1-2 μg/mL). FACS analysis (3-20 μg/mL). Immunohistochemistry on Paraffin and Frozen Sections (0.25-4 μg/mL).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Reconstitution
    Restore in distilled sterile Water to a concentration of 0.1 - 1.0 mg/mL.
    Buffer
    PBS, pH 7.4, without preservatives or stabilizers
    Preservative
    Without preservative
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    The lyophilized IgG is stable at 2-8 °C for one month and at -20 °C for longer. When reconstituted the antibody is stable for at least six weeks at 2-8 °C. For longer store in aliquots at -20 °C.
  • Nakao, Zandi, Faez, Kohno, Hafezi-Moghadam: "Discontinuous LYVE-1 expression in corneal limbal lymphatics: dual function as microvalves and immunological hot spots." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 26, Issue 2, pp. 808-17, (2012) (PubMed).

    Heishi, Hosaka, Suzuki, Miyashita, Oike, Takahashi, Nakamura, Arioka, Mitsuda, Takakura, Hojo, Matsumoto, Yamauchi, Ohta, Sonoda, Sato: "Endogenous angiogenesis inhibitor vasohibin1 exhibits broad-spectrum antilymphangiogenic activity and suppresses lymph node metastasis." in: The American journal of pathology, Vol. 176, Issue 4, pp. 1950-8, (2010) (PubMed).

    Conrad, Niess, Huss, Huber, von Luettichau, Nelson, Ott, Jauch, Bruns: "Multipotent mesenchymal stem cells acquire a lymphendothelial phenotype and enhance lymphatic regeneration in vivo." in: Circulation, Vol. 119, Issue 2, pp. 281-9, (2009) (PubMed).

  • Target
    LYVE1 (Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1))
    Alternative Name
    LYVE-1 (LYVE1 Products)
    Synonyms
    LYVE1 antibody, XLKD1 antibody, CRSBP-1 antibody, HAR antibody, LYVE-1 antibody, 1200012G08Rik antibody, Crsbp-1 antibody, Lyve-1 antibody, Xlkd1 antibody, lymphatic vessel endothelial hyaluronic receptor 1a antibody, lymphatic vessel endothelial hyaluronan receptor 1 antibody, lyve1a antibody, LYVE1 antibody, Lyve1 antibody
    Background
    LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41 % similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 Molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 Molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.Synonyms: CRSBP-1, CRSBP1, Cell surface retention sequence-binding protein 1, Extracellular link domain-containing protein 1, HAR, Hyaluronic acid receptor, LYVE1, Lymphatic vessel endothelial hyaluronic acid receptor 1, XLKD1
    Gene ID
    114332
    NCBI Accession
    NP_444477
    UniProt
    Q8BHC0
    Pathways
    Glycosaminoglycan Metabolic Process
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