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Endoglin antibody (AA 26-586)

ENG Reactivity: Human WB, FACS, IF, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN115698
  • Target See all Endoglin (ENG) Antibodies
    Endoglin (ENG)
    Binding Specificity
    • 16
    • 14
    • 12
    • 12
    • 7
    • 7
    • 7
    • 7
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 26-586
    Reactivity
    • 170
    • 62
    • 44
    • 17
    • 10
    • 3
    • 2
    • 1
    Human
    Host
    • 106
    • 86
    • 16
    • 1
    • 1
    Rabbit
    Clonality
    • 106
    • 103
    • 1
    Polyclonal
    Conjugate
    • 91
    • 27
    • 25
    • 25
    • 15
    • 9
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Endoglin antibody is un-conjugated
    Application
    • 148
    • 124
    • 58
    • 57
    • 34
    • 19
    • 16
    • 15
    • 14
    • 13
    • 13
    • 6
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Purification
    Antigen-Affinity Chromatography.
    Immunogen
    Highly pure recombinant Human soluble CD105/Endoglin produced in Insect Cells. Remarks: It consists of amino acid 26 (Glu) to 586 (Leu) and is fused to a C-terminal His-tag (6xHis).
    Top Product
    Discover our top product ENG Primary Antibody
  • Application Notes
    ELISA: Use at 1-15 μg/mL. Western blot: Use at 1-2 μg/mL. Flow Cytometry: Use at 3-20 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Reconstitution
    Restore in sterile Water to a concentration of 0.1-1.0 mg/mL.
    Buffer
    PBS, pH 7.4 without preservatives and stabilizers
    Preservative
    Without preservative
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    Endoglin (ENG)
    Alternative Name
    CD105 / Endoglin (ENG Products)
    Synonyms
    ENG antibody, MGC137842 antibody, DKFZp469D0419 antibody, END antibody, HHT1 antibody, ORW1 antibody, AI528660 antibody, AI662476 antibody, CD105 antibody, S-endoglin antibody, endoglin antibody, ENG antibody, Eng antibody
    Background
    Endoglin, also known as CD105, is a Type I integral membrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated, cytoplasmic tail. Two splice variants of human endoglin, the S-endoglin and L-endoglin that differ in the length of their cytoplasmic tails have been identified. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, bone marrow pro-erythroblasts, and leukemic cells of lymphoid and myeloid lineages. Human and mouse endoglin share approximately 70 % and 97 % amino acid sequence identity in their extracellular and intracellular domains, respectively. It has clearly been shown that CD105/Endoglin is required for angiogenesis and it plays a key role in heart development. Mutations in human endoglin or ALK-1 (another type I serine/threonine receptor) lead to the vascular disorder hereditary hemorrhagic telangiectasia (HHT). Mice heterozygous for endoglin have been developed as disease models for HHT. Endoglin has been shown to be a powerful marker of neovascularization. It is also useful as a functional marker that defines long-term repopulating hematopoietic stem cells.Synonyms: END, ENG, HHT1, ORW, ORW1
    Gene ID
    9606
    UniProt
    P17813
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