CD105 (Endoglin / TGF-Beta1/3 Receptor) (AA 26-581) antibody

Details for Product No. ABIN115700
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Antigen
Synonyms CD105, AI528660, AI662476, S-endoglin, END, HHT1, ORW1
Epitope
AA 26-581
(9), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine)
(226), (95), (35), (35), (25), (13), (13), (6), (1)
Host
Rabbit
(149), (111), (42), (2), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(34), (29), (19), (10), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(197), (164), (60), (58), (50), (42), (41), (29), (23), (15), (7), (5), (4), (4), (4), (1), (1)
Pubmed 11 references available
Catalog no. ABIN115700
Quantity 0.2 mg
Price
379.50 $   Plus shipping costs $45.00
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Immunogen Highly pure recombinant Mouse soluble CD105 produced in Insect cells. The recombinant soluble CD105 consists of amino acid 26(Glu) to 581 (Gly) and is fused to a C-terminal His-tag (6xHis).
Specificity This antibody detects Mouse CD105.
Purification Protein A Chromatography (+his tag depleted)
Alternative Name CD105 / Endoglin
Background Endoglin, also known as CD105, is a Type I integral membrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated, cytoplasmic tail. Two splice variants of human endoglin, the S-endoglin and L-endoglin that differ in the length of their cytoplasmic tails have been identified. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, bone marrow pro-erythroblasts, and leukemic cells of lymphoid and myeloid lineages. Human and mouse endoglin share approximately 70% and 97 % amino acid sequence identity in their extracellular and intracellular domains, respectively. It has clearly been shown that CD105/Endoglin is required for angiogenesis and it plays a key role in heart evelopment. Mutations in human endoglin or ALK-1 (another type I serine/threonine receptor) lead to the vascular isorder hereditary hemorrhagic telangiectasia (HHT). Mice heterozygous for endoglin have been developed as disease models for HHT. Endoglin has been shown to be a powerful marker of neovascularization. It is also useful as a functional marker that defines long-term repopulating hematopoietic stem cells.
Alternate names: END, ENG, HHT1, ORW, ORW1
NCBI Accession 10090
UniProt Q63961
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes ELISA (1-15 µg/ml). Western blot (1-2 µg/ml). Flow Cytometry (3-20 µg/ml). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore with sterile water to a concentration of 0.1-1.0 mg/mL
Buffer PBS, pH 7.2 without preservatives
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8°C. Following reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. For extended storage add glycerol to 50%.
Expiry Date 12 months
Background publications Cheifetz, Bellón, Calés et al.: "Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells." in: The Journal of biological chemistry, Vol. 267, Issue 27, pp. 19027-30, 1992 (PubMed).

McAllister, Grogg, Johnson et al.: "Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1." in: Nature genetics, Vol. 8, Issue 4, pp. 345-51, 1995 (PubMed).

Barbara, Wrana, Letarte: "Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily." in: The Journal of biological chemistry, Vol. 274, Issue 2, pp. 584-94, 1999 (PubMed).

Mäkinen, Veikkola, Mustjoki et al.: "Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3." in: The EMBO journal, Vol. 20, Issue 17, pp. 4762-73, 2001 (PubMed).

Sleeman, Krishnan, Kirkin et al.: "Markers for the lymphatic endothelium: in search of the holy grail?" in: Microscopy research and technique, Vol. 55, Issue 2, pp. 61-9, 2001 (PubMed).

Mouta Carreira, Nasser, di Tomaso et al.: "LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis." in: Cancer research, Vol. 61, Issue 22, pp. 8079-84, 2001 (PubMed).

Chen, Li, de Graaf et al.: "Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 24, pp. 15468-73, 2002 (PubMed).

Jackson: "The lymphatics revisited: new perspectives from the hyaluronan receptor LYVE-1." in: Trends in cardiovascular medicine, Vol. 13, Issue 1, pp. 1-7, 2003 (PubMed).

Parker, Goldring, Philip: "Endoglin is expressed on human chondrocytes and forms a heteromeric complex with betaglycan in a ligand and type II TGFbeta receptor independent manner." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 18, Issue 2, pp. 289-302, 2003 (PubMed).

General Arthur, Ure, Smith et al.: "Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development." in: Developmental biology, Vol. 217, Issue 1, pp. 42-53, 2000 (PubMed).

Fonsatti, Del Vecchio, Altomonte et al.: "Endoglin: An accessory component of the TGF-beta-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies." in: Journal of cellular physiology, Vol. 188, Issue 1, pp. 1-7, 2001 (PubMed).

Hosts (149), (111), (42), (2), (2)
Reactivities (226), (95), (35), (35), (25), (13), (13), (6), (1)
Applications (197), (164), (60), (58), (50), (42), (41), (29), (23), (15), (7), (5), (4), (4), (4), (1), (1)
Conjugates (34), (29), (19), (10), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Epitopes (9), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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