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CCL19 antibody

CCL19 Reactivity: Human WB, EIA, Func Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN116175
  • Target See all CCL19 Antibodies
    CCL19 (Chemokine (C-C Motif) Ligand 19 (CCL19))
    Reactivity
    • 52
    • 19
    • 5
    • 2
    Human
    Host
    • 44
    • 14
    • 1
    Rabbit
    Clonality
    • 42
    • 17
    Polyclonal
    Conjugate
    • 28
    • 10
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CCL19 antibody is un-conjugated
    Application
    • 46
    • 28
    • 25
    • 13
    • 13
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA), Functional Studies (Func)
    Specificity
    This antibody reacts with human Macrophage Inflammatory Protein-3 beta (hMIP-3 beta).
    Purification
    Affinity chromatography.
    Immunogen
    Highly pure (>98%) recombinant hMIP-3 beta.
    Top Product
    Discover our top product CCL19 Primary Antibody
  • Application Notes
    Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity ofhMIP-3 beta (100 ng/mL), a concentration of 2.7 - 4.0 μg/mL of this antibody is required. ELISA: To detect hMIP-3 beta by direct ELISA (using 100 l/well antibody solution) aconcentration of at least 0.5 μg/mL of this antibody is required. This antigen affinitypurified antibody, in conjunction with compatible secondary reagents, allows the detectionof 0.2-0.4 ng/well of recombinant hMIP-3 beta. Western Blot: To detect hMIP-3 beta by Western Blot analysis this antibody can be used ata concentration of 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagentsthe detection limit for recombinant hMIP-3 beta is 1.5 - 3.0 ng/lane, under either reducingor non-reducing conditions.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Reconstitution
    Restore in sterile water to a concentration of 0.1-1.0 mg/mL.
    Buffer
    PBS, pH 7.2 without preservatives.
    Preservative
    Without preservative
    Handling Advice
    Avoid repeated freezing and thawing. Centrifuge vial prior to opening!
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.
  • Target
    CCL19 (Chemokine (C-C Motif) Ligand 19 (CCL19))
    Alternative Name
    MIP3-beta / CCL19 (CCL19 Products)
    Synonyms
    CKb11 antibody, ELC antibody, MIP-3b antibody, MIP3B antibody, SCYA19 antibody, CCL19 antibody, Scya19 antibody, exodus-3 antibody, C-C motif chemokine ligand 19 antibody, chemokine (C-C motif) ligand 19 antibody, CCL19 antibody, ccl19 antibody, Ccl19 antibody
    Background
    MIP3 chemokines are among many novel beta chemokines recently identified through bioinformatics in the Expressed Sequence Tag (EST) database. They are distantly related to other beta chemokines (20-30 % aa sequence homology). MIP3 chemokines are useful probes for studying the biology of inflammation and cell migration. Their expression is strongly up-regulated by inflammatory signals and down-regulated by the anti-inflammatory cytokine IL10. MIP3 beta is also known as ELC (EBI1-1 ligand chemokine) and is constitutively expressed in various lymphoid tissues (thymus, lymph nodes, appendix and spleen). MIP3 beta is a chemoattractant for cultured human lymphocytes, dendritic cells, human T lymphoblastoid CEM NKR2 and hemopoietic progenitor cells. It may be involved in G Protein activation in human NK cells. MIP3 beta is a unique functional ligand for CCR7. The MIP3 beta gene has been mapped to chormosome 9p13.Synonyms: Beta chemokine exodus-3, C-C motif chemokine 19, CCL-19, CK beta-11, EBI1-ligand chemokine, ELC, Exodus-3, MIP-3 beta, MIP3B, Macrophage inflammatory protein 3 beta, SCYA19, Small-inducible cytokine A19, Small-inducible cytokine A19
    Gene ID
    6363
    NCBI Accession
    NP_006265
    UniProt
    Q99731
    Pathways
    Positive Regulation of Immune Effector Process
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