Cyclin E1 (CCNE1) antibody

Details for Product No. ABIN116512
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Antigen
Synonyms CCNE, AW538188, CycE1, Ccne, CYCLE, ccne, cycE3, cyclinE, CCNE1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(222), (53), (47), (12), (12), (12), (12), (6), (1)
Host
Rabbit
(202), (42), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(8), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Application
ELISA, Immunoprecipitation (IP), Western Blotting (WB)
(146), (74), (72), (57), (56), (50), (36), (20), (14), (5), (5), (3), (2), (1), (1), (1)
Pubmed 2 references available
Catalog no. ABIN116512
Quantity 0.1 mL
Price
390.50 $   Plus shipping costs $45.00
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Immunogen Full length synthetic polypeptide corresponding to the human gene sequence.
Specificity This product was prepared from monospecific antiserum by delipidation and defibrination. Antiserum will specifically react with a 45 kDa Cyclin E protein. No reaction was observed against other related cyclins. Cross reactivity with Cyclin E from other species may also occur.
Purification Serum
Alternative Name Cyclin E1
Background Cyclin E is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.
Alternate names: CCNE, CCNE1, Cyclin-E1
Gene ID 898
NCBI Accession NP_001229.1
UniProt P24864
Research Area Cell Cycle
Application Notes ELISA: 1: 2,000. Immunoprecipitation. Western Blot: 1: 200 to 1: 500. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 85 mg/mL (by Refractometry)
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Koff, Cross, Fisher et al.: "Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family." in: Cell, Vol. 66, Issue 6, pp. 1217-28, 1991 (PubMed).

General Claudio, De Luca, Howard et al.: "Functional analysis of pRb2/p130 interaction with cyclins." in: Cancer research, Vol. 56, Issue 9, pp. 2003-8, 1996 (PubMed).

Hosts (202), (42), (1)
Reactivities (222), (53), (47), (12), (12), (12), (12), (6), (1)
Applications (146), (74), (72), (57), (56), (50), (36), (20), (14), (5), (5), (3), (2), (1), (1), (1)
Conjugates (8), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Epitopes (35), (28), (26), (5), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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