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CD40 antibody

CD40 Reactivity: Mouse FACS, Func Host: Rat Monoclonal FGK45 unconjugated
Catalog No. ABIN1169011
  • Target See all CD40 Antibodies
    CD40
    Reactivity
    • 188
    • 96
    • 20
    • 20
    • 7
    • 6
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Mouse
    Host
    • 103
    • 100
    • 42
    • 3
    • 1
    • 1
    • 1
    Rat
    Clonality
    • 155
    • 89
    • 5
    Monoclonal
    Conjugate
    • 118
    • 22
    • 20
    • 20
    • 12
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD40 antibody is un-conjugated
    Application
    • 144
    • 92
    • 62
    • 50
    • 30
    • 28
    • 18
    • 18
    • 17
    • 14
    • 13
    • 13
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Flow Cytometry (FACS), Functional Studies (Func)
    Specificity
    Recognizes mouse CD40.
    Cross-Reactivity
    Mouse (Murine)
    Purification
    Purified from concentrated hybridoma tissue culture supernatant.
    Purity
    >95 % (SDS-PAGE)
    Endotoxin Level
    <0.01EU/μg purified protein (LAL test, Lonza).
    Immunogen
    Recombinant mouse CD40 fusion protein.
    Clone
    FGK45
    Isotype
    IgG2a
    Top Product
    Discover our top product CD40 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Comment

    Widely used stimulatory MAb to CD40. Shown to indirectly activate natural killer (NK) cells, producing significant antitumor and antimetastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    In PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.
    Expiry Date
    12 months
  • Greene, DeVecchio, Gould, Auletta, Heinzel: "In vivo and in vitro regulation of type I IFN synthesis by synergistic effects of CD40 and type II IFN." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 10, pp. 5995-6003, (2006) (PubMed).

    Hellings, Kasran, Bullens, Overbergh, Mathieu, Heremans, Matthys, Boon, Jorissen, Ceuppens: "IL-10- and IL-12-independent down-regulation of allergic sensitization by stimulation of CD40 signaling." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 8, pp. 5138-44, (2006) (PubMed).

    Honda, Yanai, Negishi, Asagiri, Sato, Mizutani, Shimada, Ohba, Takaoka, Yoshida, Taniguchi: "IRF-7 is the master regulator of type-I interferon-dependent immune responses." in: Nature, Vol. 434, Issue 7034, pp. 772-7, (2005) (PubMed).

    Erlebacher, Zhang, Parlow, Glimcher: "Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system." in: The Journal of clinical investigation, Vol. 114, Issue 1, pp. 39-48, (2004) (PubMed).

    McGregor, Schoenberger, Green: "CD154 is a negative regulator of autoaggressive CD8+ T cells in type 1 diabetes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 25, pp. 9345-50, (2004) (PubMed).

    Turner, Rakhmilevich, Burdelya, Neal, Imboden, Sondel, Yu: "Anti-CD40 antibody induces antitumor and antimetastatic effects: the role of NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 1, pp. 89-94, (2001) (PubMed).

    Mauri, Mars, Londei: "Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process." in: Nature medicine, Vol. 6, Issue 6, pp. 673-9, (2000) (PubMed).

    Rolink, Andersson, Melchers: "Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity." in: European journal of immunology, Vol. 28, Issue 11, pp. 3738-48, (1998) (PubMed).

  • Target
    CD40
    Alternative Name
    CD40 (CD40 Products)
    Synonyms
    Bp50 antibody, CDW40 antibody, TNFRSF5 antibody, p50 antibody, AI326936 antibody, GP39 antibody, HIGM1 antibody, IGM antibody, IMD3 antibody, T-BAM antibody, TRAP antibody, Tnfrsf5 antibody, TNFSF5 antibody, CD40 molecule antibody, CD40 antigen antibody, CD40 antibody, Cd40 antibody
    Background
    CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.
    UniProt
    P27512
    Pathways
    NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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