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IDO1 antibody

IDO1 Reactivity: Human WB, ELISA, FACS, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1169196
  • Target See all IDO1 Antibodies
    IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))
    Reactivity
    • 61
    • 31
    • 16
    • 8
    • 1
    • 1
    • 1
    Human
    Host
    • 56
    • 11
    • 1
    • 1
    Rabbit
    Clonality
    • 55
    • 15
    Polyclonal
    Conjugate
    • 47
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IDO1 antibody is un-conjugated
    Application
    • 62
    • 31
    • 23
    • 18
    • 16
    • 15
    • 14
    • 8
    • 7
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)
    Specificity
    Recognizes human IDO. Detects a band of ~45 kDa by Western blot.
    Cross-Reactivity
    Human
    Sterility
    0.2 μm filtered
    Immunogen
    Recombinant human IDO.
    Top Product
    Discover our top product IDO1 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
    Preservative
    Without preservative
    Storage
    4 °C,-20 °C
    Storage Comment
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 6 months after receipt when stored at -20°C.
    Expiry Date
    6 months
  • Pietra, Manzini, Rivara, Vitale, Cantoni, Petretto, Balsamo, Conte, Benelli, Minghelli, Solari, Gualco, Queirolo, Moretta, Mingari: "Melanoma cells inhibit natural killer cell function by modulating the expression of activating receptors and cytolytic activity." in: Cancer research, Vol. 72, Issue 6, pp. 1407-15, (2012) (PubMed).

    Opitz, Litzenburger, Opitz, Sahm, Ochs, Lutz, Wick, Platten: "The indoleamine-2,3-dioxygenase (IDO) inhibitor 1-methyl-D-tryptophan upregulates IDO1 in human cancer cells." in: PLoS ONE, Vol. 6, Issue 5, pp. e19823, (2011) (PubMed).

    Curti, Trabanelli, Onofri, Aluigi, Salvestrini, Ocadlikova, Evangelisti, Rutella, De Cristofaro, Ottaviani, Baccarani, Lemoli: "Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells." in: Haematologica, Vol. 95, Issue 12, pp. 2022-30, (2010) (PubMed).

    Maby-El Hajjami, Amé-Thomas, Pangault, Tribut, DeVos, Jean, Bescher, Monvoisin, Dulong, Lamy, Fest, Tarte: "Functional alteration of the lymphoma stromal cell niche by the cytokine context: role of indoleamine-2,3 dioxygenase." in: Cancer research, Vol. 69, Issue 7, pp. 3228-37, (2009) (PubMed).

    Boasso, Herbeuval, Hardy, Anderson, Dolan, Fuchs, Shearer: "HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells." in: Blood, Vol. 109, Issue 8, pp. 3351-9, (2007) (PubMed).

  • Target
    IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))
    Alternative Name
    IDO (IDO1 Products)
    Synonyms
    INDO antibody, ido antibody, indo antibody, IDO antibody, cd107b antibody, IDO1 antibody, IDO-1 antibody, Ido antibody, Indo antibody, indoleamine 2,3-dioxygenase 1 antibody, indoleamine 2,3-dioxygenase 1 L homeolog antibody, indoleamine 2,3-dioxygenase 1-like antibody, IDO1 antibody, ido1.L antibody, ido1 antibody, Ido1 antibody, LOC100050681 antibody
    Background
    IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T-cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T-cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.
    UniProt
    P14902
    Pathways
    Activated T Cell Proliferation
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