TNFRSF10B antibody
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- Target See all TNFRSF10B Antibodies
- TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This TNFRSF10B antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Immunohistochemistry (IHC)
- Specificity
- Recognizes human TRAIL-R2.
- Cross-Reactivity
- Human
- Cross-Reactivity (Details)
- Does not cross-react with human TRAIL-R1, -R3 or -R4.
- Purification
- Purified from concentrated hybridoma tissue culture supernatant.
- Purity
- >95 % (SDS-PAGE)
- Immunogen
- Recombinant human TRAIL-R2 (DR5).
- Clone
- TR2-21
- Isotype
- IgG1
- Top Product
- Discover our top product TNFRSF10B Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Specially developed for the immunohistochemical detection of TRAIL-R2 in paraffin embedded tissue. Has been shown to detect TRAIL-R2 expressed at endogenous levels in paraffin-embedded tissue in different mammary carcinoma tissues.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- In PBS containing 10 % glycerol and 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. - Expiry Date
- 12 months
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- Target
- TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))
- Alternative Name
- TRAIL-R2 (TNFRSF10B Products)
- Synonyms
- TNFRSF10B antibody, dr5 antibody, cd262 antibody, killer antibody, trick2 antibody, trickb antibody, xDR-M1 antibody, xDR-M2 antibody, ztnfr9 antibody, trailr2 antibody, trick2a antibody, trick2b antibody, CD262 antibody, DR5 antibody, KILLER antibody, KILLER/DR5 antibody, TRAIL-R2 antibody, TRAILR2 antibody, TRICK2 antibody, TRICK2A antibody, TRICK2B antibody, TRICKB antibody, ZTNFR9 antibody, Ly98 antibody, MK antibody, tumor necrosis factor receptor superfamily, member 10b antibody, tumor necrosis factor receptor superfamily member 10b S homeolog antibody, tumor necrosis factor receptor superfamily member 10b L homeolog antibody, tumor necrosis factor receptor superfamily member 10b antibody, TNF receptor superfamily member 10b antibody, Tnfrsf10b antibody, TNFRSF10B antibody, tnfrsf10b.S antibody, tnfrsf10b.L antibody, tnfrsf10b antibody
- Background
- TRAIL-R2 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.
- UniProt
- O14763
- Pathways
- p53 Signaling, Apoptosis, Positive Regulation of Endopeptidase Activity
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