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TNFRSF10B antibody

TNFRSF10B Reactivity: Human FACS, IHC Host: Mouse Monoclonal TR2-21 unconjugated
Catalog No. ABIN1169244
  • Target See all TNFRSF10B Antibodies
    TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))
    Reactivity
    • 99
    • 18
    • 4
    • 1
    • 1
    Human
    Host
    • 64
    • 39
    • 3
    • 1
    • 1
    • 1
    Mouse
    Clonality
    • 61
    • 45
    • 2
    Monoclonal
    Conjugate
    • 73
    • 10
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TNFRSF10B antibody is un-conjugated
    Application
    • 74
    • 35
    • 31
    • 25
    • 17
    • 16
    • 15
    • 13
    • 12
    • 11
    • 8
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunohistochemistry (IHC)
    Specificity
    Recognizes human TRAIL-R2.
    Cross-Reactivity
    Human
    Cross-Reactivity (Details)
    Does not cross-react with human TRAIL-R1, -R3 or -R4.
    Purification
    Purified from concentrated hybridoma tissue culture supernatant.
    Purity
    >95 % (SDS-PAGE)
    Immunogen
    Recombinant human TRAIL-R2 (DR5).
    Clone
    TR2-21
    Isotype
    IgG1
    Top Product
    Discover our top product TNFRSF10B Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Comment

    Specially developed for the immunohistochemical detection of TRAIL-R2 in paraffin embedded tissue. Has been shown to detect TRAIL-R2 expressed at endogenous levels in paraffin-embedded tissue in different mammary carcinoma tissues.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    In PBS containing 10 % glycerol and 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.
    Expiry Date
    12 months
  • Target
    TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))
    Alternative Name
    TRAIL-R2 (TNFRSF10B Products)
    Synonyms
    TNFRSF10B antibody, dr5 antibody, cd262 antibody, killer antibody, trick2 antibody, trickb antibody, xDR-M1 antibody, xDR-M2 antibody, ztnfr9 antibody, trailr2 antibody, trick2a antibody, trick2b antibody, CD262 antibody, DR5 antibody, KILLER antibody, KILLER/DR5 antibody, TRAIL-R2 antibody, TRAILR2 antibody, TRICK2 antibody, TRICK2A antibody, TRICK2B antibody, TRICKB antibody, ZTNFR9 antibody, Ly98 antibody, MK antibody, tumor necrosis factor receptor superfamily, member 10b antibody, tumor necrosis factor receptor superfamily member 10b S homeolog antibody, tumor necrosis factor receptor superfamily member 10b L homeolog antibody, tumor necrosis factor receptor superfamily member 10b antibody, TNF receptor superfamily member 10b antibody, Tnfrsf10b antibody, TNFRSF10B antibody, tnfrsf10b.S antibody, tnfrsf10b.L antibody, tnfrsf10b antibody
    Background
    TRAIL-R2 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.
    UniProt
    O14763
    Pathways
    p53 Signaling, Apoptosis, Positive Regulation of Endopeptidase Activity
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