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NLRP1 antibody (N-Term)

NLRP1 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1169419
  • Target See all NLRP1 Antibodies
    NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))
    Binding Specificity
    • 15
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 2-25, N-Term
    Reactivity
    • 37
    • 18
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 35
    • 2
    • 1
    Rabbit
    Clonality
    • 38
    Polyclonal
    Conjugate
    • 17
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NLRP1 antibody is un-conjugated
    Application
    • 28
    • 13
    • 13
    • 11
    • 7
    • 6
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Specificity
    Recognizes human NLRP1/NALP1.
    Cross-Reactivity
    Human
    No Cross-Reactivity
    Mouse (Murine)
    Cross-Reactivity (Details)
    Does not cross-react with mouse NLRP1/NALP1.
    Immunogen
    Synthetic peptide corresponding to aa 2-25 (A2GGAWGRLACYLEFLKKEELKEFQ25) at the N-terminus of human NLRP1/NALP1.
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    Discover our top product NLRP1 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    In PBS containing 10 % glycerol and 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.
    Expiry Date
    12 months
  • Target
    NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))
    Alternative Name
    NLRP1/NALP1 (NLRP1 Products)
    Synonyms
    CARD7 antibody, CIDED antibody, CLR17.1 antibody, DEFCAP antibody, DEFCAP-L/S antibody, NAC antibody, NALP1 antibody, PP1044 antibody, SLEV1 antibody, VAMAS1 antibody, NLR family pyrin domain containing 1 antibody, NLRP1 antibody, Nlrp1 antibody
    Background
    NALP1/NLRP1 is able to form cytoplasmic structures termed death effector filaments. It enhances and stimulates apoptosis through activation of different caspase cascades. It is involved in the activation of caspase-1 and caspase-5 as part of the NALP1 inflammasome complex which leads to processing and release of IL1B and IL18. Genetic variations in the NLRP1/NALP1 gene are associated with susceptibility to vitiligo-associated multiple autoimmune disease type 1, an autoimmune disorder characterized by the association of vitiligo with several autoimmune and autoinflammatory diseases including autoimmune thyroid disease, rheumatoid arthritis and systemic lupus erythematosus.
    UniProt
    Q9C000
    Pathways
    Positive Regulation of Endopeptidase Activity, Inflammasome
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