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TWEAK antibody

TNFSF12 Reactivity: Human FACS Host: Mouse Monoclonal CARL unconjugated
Catalog No. ABIN1176948
  • Target See all TWEAK (TNFSF12) Antibodies
    TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))
    Reactivity
    • 62
    • 25
    • 15
    • 4
    • 1
    • 1
    • 1
    Human
    Host
    • 45
    • 11
    • 10
    • 2
    Mouse
    Clonality
    • 56
    • 11
    • 1
    Monoclonal
    Conjugate
    • 39
    • 10
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This TWEAK antibody is un-conjugated
    Application
    • 40
    • 26
    • 17
    • 13
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    Flow Cytometry (FACS)
    Brand
    BD Pharmingen™
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Sterility
    0.2 μm filtered
    Endotoxin Level
    Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
    Immunogen
    Human Tweak Transfected Cell Line
    Clone
    CARL
    Isotype
    IgG3 kappa
    Top Product
    Discover our top product TNFSF12 Primary Antibody
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.0 mg/mL
    Buffer
    No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
    Preservative
    Azide free
    Storage
    4 °C
    Storage Comment
    Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
  • Llinàs, Lázaro, de Salort, Matesanz-Isabel, Sintes, Engel: "Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometry." in: Immunology letters, Vol. 134, Issue 2, pp. 113-21, (2010) (PubMed).

    Xu, Okamoto, Ichikawa, Ando, Tasaka, Masuyama, Ogawa, Yagita, Okumura, Nakao: "TWEAK/Fn14 interaction stimulates human bronchial epithelial cells to produce IL-8 and GM-CSF." in: Biochemical and biophysical research communications, Vol. 318, Issue 2, pp. 422-7, (2004) (PubMed).

    Nakayama, Kayagaki, Yamaguchi, Okumura, Yagita: "Involvement of TWEAK in interferon gamma-stimulated monocyte cytotoxicity." in: The Journal of experimental medicine, Vol. 192, Issue 9, pp. 1373-80, (2000) (PubMed).

    Lynch, Wang, Lund, Chen, Leal, Wiley: "TWEAK induces angiogenesis and proliferation of endothelial cells." in: The Journal of biological chemistry, Vol. 274, Issue 13, pp. 8455-9, (1999) (PubMed).

    Chicheportiche, Bourdon, Xu, Hsu, Scott, Hession, Garcia, Browning: "TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis." in: The Journal of biological chemistry, Vol. 272, Issue 51, pp. 32401-10, (1998) (PubMed).

  • Target
    TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))
    Alternative Name
    TWEAK (TNFSF12 Products)
    Synonyms
    APO3L antibody, DR3LG antibody, TWEAK antibody, Apo3l antibody, Dr3l antibody, Dr3lg antibody, Tweak antibody, TNF superfamily member 12 antibody, tumor necrosis factor (ligand) superfamily, member 12 antibody, TNFSF12 antibody, Tnfsf12 antibody
    Background
    The CARL-1 monoclonal antibody specifically binds to TWEAK, also known as TNF-related WEAK inducer of apoptosis. The TWEAK cytokine belongs to the tumor necrosis factor (TNF) ligand family and is encoded by the TNFSF12 (Tumor necrosis factor ligand superfamily member 12) gene. TWEAK is present as a type II transmembrane protein form and a smaller, biologically-active secreted isoform. TWEAK is expressed on most tissues and non-lymphoid tumor cell lines but has weak or no expression on hematopoietic lineage cell lines. TWEAK is not detectable on resting peripheral blood mononuclear cells. However, its expression is upregulated on peripheral blood monocytes in response to IFN-gamma stimulation. TWEAK can act through the TWEAK Receptor (aka, TWEAK-R, TNFRSF12A, Fn14, and CD266) to induce a variety of target cellular responses including NF-kB activation, proliferation, apoptosis, IL-8 and GM-CSF production. Clone CARL-2, a different monoclonal antibody, also binds to TWEAK although it binds to a different TWEAK epitope.
    Synonyms: TNFSF12, APO3 ligand, APO3L, DR3LG, TNF-related WEAK inducer of apoptosis
    Pathways
    Apoptosis
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