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STAT4 antibody (pTyr693) (PE)

STAT4 Reactivity: Human, Mouse ICS Host: Mouse Monoclonal 38-p PE
Catalog No. ABIN1177204
  • Target See all STAT4 Antibodies
    STAT4 (Signal Transducer and Activator of Transcription 4 (STAT4))
    Binding Specificity
    • 33
    • 11
    • 8
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr693
    Reactivity
    • 88
    • 53
    • 35
    • 5
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    Human, Mouse
    Host
    • 96
    • 6
    • 2
    • 2
    Mouse
    Clonality
    • 87
    • 19
    Monoclonal
    Conjugate
    • 54
    • 8
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This STAT4 antibody is conjugated to PE
    Application
    • 78
    • 48
    • 41
    • 24
    • 22
    • 16
    • 13
    • 13
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Intracellular Staining (ICS)
    Brand
    BD Phosflow™
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Phosphorylated Human Stat4 (pY693)
    Clone
    38-p
    Isotype
    IgG2b kappa
    Top Product
    Discover our top product STAT4 Primary Antibody
  • Sample Volume
    20 μL
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
  • Kisseleva, Bhattacharya, Braunstein, Schindler: "Signaling through the JAK/STAT pathway, recent advances and future challenges." in: Gene, Vol. 285, Issue 1-2, pp. 1-24, (2002) (PubMed).

    Visconti, Gadina, Chiariello, Chen, Stancato, Gutkind, OShea: "Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity." in: Blood, Vol. 96, Issue 5, pp. 1844-52, (2000) (PubMed).

  • Target
    STAT4 (Signal Transducer and Activator of Transcription 4 (STAT4))
    Alternative Name
    Stat4 (STAT4 Products)
    Synonyms
    SLEB11 antibody, signal transducer and activator of transcription 4 antibody, STAT4 antibody, stat4 antibody, Stat4 antibody
    Background
    The Stat proteins function both as cytoplasmic signal transducers and as activators of transcription. Seven mammalian Stat proteins have been identified: Stat1-4, Stat5a, 5b, and Stat6. Stat4 has been shown to play an important role in development of T helper cells, specifically the Th1 subset. Stat4 is activated by IL-12 and by type 1 interferons. Knockout mice supported the role that Stat4 plays in IL-12 signaling because lymphocytes from Stat 4-/- mice could not differentiate into Th1 cells or produce IFNgamma in response to treatment with IL-12. IFNgamma plays an important role in host defense. A key component in the activation of Stat4 is the phosphorylation on tyrosine and serine residues in response to IL-12 stimulation. IL-12 stimulation leads to the phosphorylation of Stat4 on tyrosine 693 and serine 721. Transcriptional activity of Stat4 has been shown to be significantly reduced when residues Y693 and S721 are mutated.
    Pathways
    JAK-STAT Signaling
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