PDCD1LG2 antibody

Catalog No. ABIN1177350

Product Details anti-PDCD1LG2 Antibody

Target: PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PDCD1LG2 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Brand: BD Pharmingen™

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Sterility: 0.2 μm filtered

Endotoxin Level: Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

Clone: MIH18

Isotype: IgG1 kappa

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

Preservative: Azide free

Storage: 4 °C

Storage Comment: Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

References for anti-PDCD1LG2 antibody (ABIN1177350)

Ohigashi, Sho, Yamada, Tsurui, Hamada, Ikeda, Mizuno, Yoriki, Kashizuka, Yane, Tsushima, Otsuki, Yagita, Azuma, Nakajima: "Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 11, Issue 8, pp. 2947-53, (2005) (PubMed).

Bennett, Luxenberg, Ling, Wang, Marquette, Lowe, Khan, Veldman, Jacobs, Valge-Archer, Collins, Carreno: "Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 2, pp. 711-8, (2003) (PubMed).

Brown, Dorfman, Ma, Sullivan, Munoz, Wood, Greenfield, Freeman: "Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 3, pp. 1257-66, (2003) (PubMed).

Carter, Fouser, Jussif, Fitz, Deng, Wood, Collins, Honjo, Freeman, Carreno: "PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2." in: European journal of immunology, Vol. 32, Issue 3, pp. 634-43, (2002) (PubMed).

Latchman, Wood, Chernova, Chaudhary, Borde, Chernova, Iwai, Long, Brown, Nunes, Greenfield, Bourque, Boussiotis, Carter, Carreno, Malenkovich, Nishimura, Okazaki, Honjo, Sharpe, Freeman: "PD-L2 is a second ligand for PD-1 and inhibits T cell activation." in: Nature immunology, Vol. 2, Issue 3, pp. 261-8, (2001) (PubMed).

Target Details for PDCD1LG2

Target: PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))

Alternative Name: CD273 (PDCD1LG2 Products)

Synonyms: PDL2 antibody, B7DC antibody, Btdc antibody, CD273 antibody, PD-L2 antibody, PDCD1L2 antibody, bA574F11.2 antibody, B7-DC antibody, F730015O22Rik antibody, programmed cell death 1 ligand 2 antibody, PDCD1LG2 antibody, Pdcd1lg2 antibody

Background: The MIH18 monoclonal antibody specifically binds to CD273, the Programmed Death Ligand 2 (PD-L2). PD-L1 and PD-L2 are newly discovered members of the B7 family that are the ligands for the Programmed Death 1 (PD-1) receptor. They are expressed on immature dendritic cells and mature dendritic cells. PD-L1 is expressed on antigen-presenting cells, including IFN-g-stimulated monocytes and activated human and mouse dendritic cells. Monoclonal antibodies that block PD- 1 and PD-L2 on dendritic cells result in enhanced T cell proliferation and cytokine production. PD-L2, also called B7-DC, is expressed on placental trophoblasts, myocardial endothelium and medullary thymic epithelial cells. Studies show overlapping functions of PD-L1 and PD-L2 and indicate an important role for the PD-L:PD-1 pathway in regulating T cell responses.
Synonyms: PDCD1LG2, PDCD1 ligand 2, PDCD1L2, PD-1 ligand 2, PD-L2, PDL2, B7-DC, Btdc