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Integrin, alpha 6 (ITGA6) antibody (Biotin)

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Synonyms inta6, ITGA6, im:6897425, itga6, si:dkey-32o22.1, wu:fb80g02, LOC100221694, 5033401O05Rik, AI115430, Cd49f, VLA-6, CD49f, ITGA6B
Dog (Canine), Human, Monkey, Mouse (Murine), Pig (Porcine)
(273), (95), (35), (17), (16), (11), (8), (6), (2), (2), (2), (2), (1), (1), (1)
(104), (100), (99), (2)
Clonality (Clone)
Monoclonal ()
(40), (32), (18), (5), (5), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Flow Cytometry (FACS)
(183), (104), (74), (51), (47), (42), (28), (19), (11), (8), (7), (7), (5), (3), (2), (2), (2), (1)
Pubmed 6 references available
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Quantity 0.1 mg
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Immunogen BALB/c mouse mammary tumour cells. Spleen cells from immunised Sprague-Dawley rats were fused with cells of the SP2/0 mouse myeloma cell line
Clone NKI-GoH3
Isotype IgG2a
Specificity This antibody recognises CD49F (VLA-6 alpha chain). Clone NKI-GoH3 reacts with platelets, megakaryocytes, T lymphocytes and common Acute Lymphoblastic Leukaemia cells (alpha-6 beta-1). In immunohistology the monoclonal antibody reacts with epithelial cells of a variety of tissues, peripheral nerves, microvascular endothelial cells, placenta cyto- and syncytotrophoblasts.VLA-6 is an important mediator of cell binding to laminin. Studies suggest that clone GoH3 specifically blocks the binding of cells to the E8 fragment of laminin.
Purification Affinity chromatography on Protein G
Alternative Name CD49f / ITGA6 (ITGA6 Antibody Abstract)
Background CD49F is a 120kD cell surface glycoprotein that can form distinct complexes with CD29 (VLA beta-chain), resulting in the VLA-6 (alpha-6 beta-1) complex, which is expressed on human platelets, or with the beta-4 integrin resulting in the alpha-6 beta-4 complex which is expressed on various human epithelial cells.Synonyms: CD49 antigen-like family member F, Integrin alpha-6, VLA-6, VLA6
Gene ID 3655
NCBI Accession NP_000201
UniProt P23229
Application Notes Flow cytometry: use 10 μL of neat - 1/5 diluted antibody to label 10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide and 1 % Bovine Serum Albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-Integrin, alpha 6 (ITGA6) antibody (Biotin) (ABIN118231) Staining of human peripheral blood lymphocytes with RAT ANTI HUMAN/MOUSE CD49f:BIOTIN
Background publications Galkowska, Waldemar, Wojewodzka: "Reactivity of antibodies directed against human antigens with surface markers on canine leukocytes." in: Veterinary immunology and immunopathology, Vol. 53, Issue 3-4, pp. 329-34, 1997 (PubMed).

Sonnenberg, Janssen, Hogervorst et al.: "A complex of platelet glycoproteins Ic and IIa identified by a rat monoclonal antibody." in: The Journal of biological chemistry, Vol. 262, Issue 21, pp. 10376-83, 1987 (PubMed).

Sonnenberg, Modderman, Hogervorst: "Laminin receptor on platelets is the integrin VLA-6." in: Nature, Vol. 336, Issue 6198, pp. 487-9, 1989 (PubMed).

Hemler, Crouse, Takada et al.: "Multiple very late antigen (VLA) heterodimers on platelets. Evidence for distinct VLA-2, VLA-5 (fibronectin receptor), and VLA-6 structures." in: The Journal of biological chemistry, Vol. 263, Issue 16, pp. 7660-5, 1988 (PubMed).

Sonnenberg, Daams, Van der Valk et al.: "Development of mouse mammary gland: identification of stages in differentiation of luminal and myoepithelial cells using monoclonal antibodies and polyvalent antiserum against keratin." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 34, Issue 8, pp. 1037-46, 1986 (PubMed).

Sonnenberg, Linders, Modderman et al.: "Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8." in: The Journal of cell biology, Vol. 110, Issue 6, pp. 2145-55, 1990 (PubMed).

Catalog No. ABIN118231
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