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CD4 antibody (CD4 Molecule) (PE)

Details for Product anti-CD4 Antibody No. ABIN118488, Supplier: Log in to see
Antigen
  • cd4
  • CD4mut
  • L3T4
  • Ly-4
  • p55
  • W3/25
Alternatives
anti-Human CD4 antibody for Flow Cytometry
Reactivity
Human
1197
691
240
66
52
45
25
23
22
21
19
15
14
9
9
8
7
7
7
7
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5
5
5
3
2
2
2
1
1
1
Host
Mouse
1358
664
276
4
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This CD4 antibody is conjugated to PE
282
236
175
114
44
42
42
39
39
38
36
32
26
24
22
22
21
20
19
19
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19
16
15
13
9
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5
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4
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3
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3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
1802
436
395
352
309
297
179
136
100
70
33
28
28
27
22
18
14
11
10
9
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6
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5
4
3
2
2
2
2
2
2
1
1
1
1
1
1
1
Supplier
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Immunogen Human PHA blasts. Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.
Clone RPA-T4
Isotype IgG1
Specificity This antibody recognises CD4. Epitope mapping studies have shown that antibodies, produced by clone RPA-T4, recognise an epitope within domain 1, of the extracellular region, of the CD4 Molecule. Clone RPA-T4 has been reported to block gp120-CD4 interaction and inhibit syncytium formation. We recommend the use of SM1058LE for this purpose.
Purification Affinity Chromatography on Protein G
Alternative Name CD4 (CD4 Antibody Abstract)
Background CD4 is a 55kD cell surface glycoprotein that is primarily expressed on a subpopulation of T lymphocytes, on peripheral blood monocytes and on tissue macrophages.Synonyms: T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4
Gene ID 920
NCBI Accession NP_000607
UniProt P01730
Research Area Immunology, Adaptive Immunity, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells
Pathways TCR Signaling
Application Notes Flow Cytometry: Use 10 μL of neat-1/10 diluted antibody to label 10^6 cells or 100 μL of whole blood.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with distilled water
Concentration 0.1 mg/mL
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Prior to and following reconstitution store the antibody at -20 °C.
Supplier Images
Flow Cytometry (FACS) image for anti-CD4 antibody (CD4 Molecule)  (PE) (ABIN118488) Staining of human peripheral blood lymphocytes with MOUSE ANTI HUMAN CD4:RPE (ABIN118...
Background publications Voehringer, Koschella, Pircher: "Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1)." in: Blood, Vol. 100, Issue 10, pp. 3698-702, 2002 (PubMed).

Zarkesh-Esfahani, Pockley, Metcalfe, Bidlingmaier, Wu, Ajami, Weetman, Strasburger, Ross: "High-dose leptin activates human leukocytes via receptor expression on monocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 8, pp. 4593-9, 2001 (PubMed).