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CD27 antibody

CD27 Reactivity: Human FACS Host: Mouse Monoclonal LT27 unconjugated
Catalog No. ABIN118578
  • Target See all CD27 Antibodies
    CD27 (CD27 Molecule (CD27))
    Reactivity
    • 168
    • 52
    • 37
    • 6
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 104
    • 77
    • 15
    • 3
    • 2
    • 1
    Mouse
    Clonality
    • 112
    • 88
    • 2
    Monoclonal
    Conjugate
    • 72
    • 20
    • 19
    • 13
    • 8
    • 7
    • 4
    • 4
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    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD27 antibody is un-conjugated
    Application
    • 129
    • 79
    • 50
    • 29
    • 29
    • 17
    • 16
    • 13
    • 13
    • 13
    • 10
    • 6
    • 6
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    • 1
    Flow Cytometry (FACS)
    Specificity
    The antibody reacts with CD27 (T14), a 50-55 kDa type I transmembrane glycoprotein (member of the TNF-receptor superfamily) expressed on medullary thymocytes, peripheral T lymphocytes, some B lymphocytes and NK cells.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human
    Purification
    Precipitation methods and ion exchange chromatography
    Purity
    > 95 % (by SDS-PAGE)
    Immunogen
    Human peripheral blood lymphocytes
    Clone
    LT27
    Isotype
    IgG2a
    Top Product
    Discover our top product CD27 Primary Antibody
  • Application Notes
    Flow Cytometry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing. Dilute only prior to immediate use
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody (undiluted) at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    CD27 (CD27 Molecule (CD27))
    Alternative Name
    CD27 (CD27 Products)
    Synonyms
    TNFRSF7 antibody, S152 antibody, Tnfrsf7 antibody, Tp55 antibody, S152. LPFS2 antibody, T14 antibody, CD27 molecule antibody, CD27 antigen antibody, CD27 antibody, Cd27 antibody
    Background
    CD27 is a transmembrane 55 kDa protein of the nerve growth factor-receptor family, expressed as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells and a subpopulation of B cells. Activation of T cells via TCR-CD3 complex results in upregulation of CD27 expression on the plasma membrane as well as in the release of its soluble 28-32 kDa form, sCD27, detected in the plasma, urine or spinal fluid. This sCD27 is an important prognostic marker of acute and chronic B cell malignancies. RgpA, a cystein proteinase, although activating T cells through the protease-activated receptors (PARs), degradates CD27 and counteracts T cell activation mediated by CD27 and its ligand CD70.Synonyms: CD27L receptor, T-cell activation antigen CD27, T14, TNFRSF7, Tumor necrosis factor receptor superfamily member 7
    Gene ID
    939
    NCBI Accession
    NP_001233
    UniProt
    P26842
    Pathways
    Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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