Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1) antibody

Details for Product No. ABIN118624
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Antigen
Synonyms ENTPD1, MGC80631, zgc:100819, entpd1, MGC79567, ATPDase, CD39, NTPDase-1, 2610206B08Rik, AA408691, Cd39
Reactivity
Human
(69), (36), (23), (17), (17)
Host
Mouse
(37), (31), (12), (3), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(9), (9), (5), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Functional Studies (Func), Flow Cytometry (FACS)
(58), (39), (12), (11), (10), (10), (6), (3), (2), (1), (1), (1)
Pubmed 4 references available
Quantity 1 mg
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Catalog No. ABIN118624
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Immunogen PHA activated human lymphocytes.
Clone A1
Isotype IgG1
Specificity This antibody binds to the CD39 cell surface antigen, a 70-100 kD molecule expressed on peripheral blood B cells, monocytes and T cell clones. CD39 has intrinsic ecto-ATPase activity. Expression is induced on T cells and increased on B cells as a late activation antigen. This antibody has been shown to block MHC independent target cell recognition by hapten- specific CTL.
Purification Affinity Chromatography on Protein G.
Alternative Name CD39 / ENTPD1
Background Human CD39 is found on most mature B cells, activated NK cells and activated T cells. CD39 is also weakly expressed on granulocytes. CD39 has homology to the Nmyc family of proteins and was recently cloned. CD39 can hydrolyze both nucleoside triphosphates and diphosphates. CD39 is the dominant ecto nucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type 2 purinergic (P2) G protein coupled receptors (GPCRs). CD39 transgenic mice exhibit impaired platelet aggregation, prolonged bleeding times, and resistance to systemic thromboembolism. There is a correlation between ATP hydrolysis and triglycerides in patients with chronic heart disease, suggesting a relationship between ATP diphosphohydrolase and thrombogenesis. Depolarization causes the endothelial production of superoxide, which inhibits the activity of endothelial CD39 and enhances platelet aggregation. After exercise, all subjects showed a significant reduction of CD39 expression in platelet and an increase of CD39 expression in B lymphocytes.
Alternate names: ATPDase, Ecto-ATP diphosphohydrolase, Ecto-apyrase, Ectonucleoside triphosphate diphosphohydrolase 1, Lymphoid cell activation antigen, NTPDase 1
Gene ID 953
NCBI Accession NP_001091645
UniProt P49961
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow cytometry: 1/10 - 1/50, use 10 ul of the suggested working dilution to label 10e6 cells. Functional assays. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline pH 7.4 without preservatives.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Suranyi, Bishop, Clayberger et al.: "Lymphocyte adhesion molecules in T cell-mediated lysis of human kidney cells." in: Kidney international, Vol. 39, Issue 2, pp. 312-9, 1991 (PubMed).

Aversa, Suranyi, Waugh et al.: "Detection of a late lymphocyte activation marker by A1, a new monoclonal antibody." in: Transplantation proceedings, Vol. 20, Issue 1, pp. 49-52, 1988 (PubMed).

Stöckl, Majdic, Fischer et al.: "Monomorphic molecules function as additional recognition structures on haptenated target cells for HLA-A1-restricted, hapten-specific CTL." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 5, pp. 2724-33, 2001 (PubMed).

General Aversa, Waugh, Bishop et al.: "Use of monoclonal antibodies to study in vivo and in vitro-activated lymphocytes." in: Transplantation proceedings, Vol. 21, Issue 1 Pt 1, pp. 349-50, 1989 (PubMed).

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