Integrin Alpha2b (CD41) antibody (FITC)

Details for Product No. ABIN118657
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Antigen
Synonyms AI172977, CD41, CD41B, GpIIb, alphaIIb, BDPLT16, BDPLT2, GP2B, GPIIb, GT, GTA, HPA3
Reactivity
Human
(191), (72), (20), (12), (3), (2), (2), (1), (1)
Host
Mouse
(178), (56), (25)
Clonality (Clone)
Monoclonal ()
Conjugate
FITC
(40), (26), (22), (7), (6), (4), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS)
(199), (50), (40), (34), (27), (18), (16), (10), (10), (6), (5), (2), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN118657
412.50 $
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Immunogen Human platelet plasma membrane. Spleen cells from immunised BALB/c mice were fused with cells from the SP2/0 mouse myeloma line.
Clone PM6-248
Isotype IgG1
Specificity This antibody recognises the CD41 cell surface antigen. It has not been established if clone PM6/248 recognises free CD41 or CD41 only when complexed with CD61. However, antibody binding is reduced in the presence of EDTA suggesting that the epitope recognised is dependent upon an intact CD41/61 complex.
Purification Affinity Chromatography on Protein A.
Alternative Name CD41 / ITGA2B
Background CD41 is a 140kD glycoprotein expressed by platelets and megakaryocytes. CD41 is also known as platelet glycoprotein IIb, and functions as a receptor for fibrinogen, fibronectin and vWF.
Alternate names: GP2B, GPalpha IIb, ITGAB, Integrin alpha-IIb, Platelet membrane glycoprotein IIb
Gene ID 9606
UniProt P08514
Application Notes Flow Cytometry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.1 mg/mL
Buffer PBS, pH 7.4 containing 0.09% Sodium Azide as preservative and 1% BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Integrin Alpha2b (CD41) antibody (FITC) Staining of human peripheral blood platelets with MOUSE ANTI HUMAN CD41:FITC (ABIN118657).
General Hornby, Brown, Wilkinson et al.: "Activation of human platelets by exposure to a monoclonal antibody, PM6/248, to glycoprotein IIb-IIIa." in: British journal of haematology, Vol. 79, Issue 2, pp. 277-85, 1992 (PubMed).

Michelson, Page, Casey et al.: "An eosinophilia-myalgia syndrome related disorder associated with exposure to L-5-hydroxytryptophan." in: The Journal of rheumatology, Vol. 21, Issue 12, pp. 2261-5, 1995 (PubMed).

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