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Details for Product No. ABIN118758

Integrin beta 3 (ITGB3) antibody

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Antigen
Synonyms BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT, INGRB3, integrin
Reactivity
»Alternatives Human, Monkey
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB), Flow Cytometry (FACS)
Pubmed 3 references available
Catalog no. ABIN118758
Quantity 0.2 mg
Price
489.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Platelet plasma membrane.
Clone PM6-13
Isotype IgG1
Specificity This antibody recognises a 105 kD glycoprotein, which is the Integrin beta 3 chain.
Purification Protein A affinity chromatography
Alternative Name CD61 / ITGB3
Background Integrin beta 3 chain associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) at the cell surface. CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51. CD61 is a receptor for fibrinogen, fibronectin, vWF, vitronectin and thrombospondin.
Alternate names: GP3A, GPIIIa, Integrin beta-3, Platelet membrane glycoprotein IIIa
NCBI Accession 9606
UniProt P05106
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow cytometry (use 10 ul of 1/100 - 1/200 diluted antibody to label 10e6 cells or 100 ul of whole blood). Immunohistochemistry on frozen sections (Recommended positive control tissue: Bone marrow). Immunoprecipitation. Western Blot (Non-reducing conditions). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This antibody inhibits platelet aggregation and activation induced by thrombin and collagen.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4, with 0.09% sodium azide as preservative
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing. Dilute only prior to immediate use
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C or below for longer.
Expiry Date 12 months
Background publications Hynes: "Integrins: versatility, modulation, and signaling in cell adhesion." in: Cell, Vol. 69, Issue 1, pp. 11-25, 1992 (PubMed).

Phillips, Charo, Scarborough: "GPIIb-IIIa: the responsive integrin." in: Cell, Vol. 65, Issue 3, pp. 359-62, 1991 (PubMed).

Michelson, Page, Casey et al.: "An eosinophilia-myalgia syndrome related disorder associated with exposure to L-5-hydroxytryptophan." in: The Journal of rheumatology, Vol. 21, Issue 12, pp. 2261-5, 1995 (PubMed).

Alternatives for antigen "Integrin beta 3 (ITGB3)", type "Antibodies"
Hosts (164), (159), (41), (2), (1)
Reactivities (301), (150), (81), (48), (45), (27), (26), (8), (8), (3), (2), (1), (1), (1), (1)
Applications (182), (158), (75), (57), (49), (41), (34), (30), (17), (14), (14), (4), (3), (2), (1)
Conjugates (54), (28), (22), (7), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (1), (1), (1), (1), (1)
Epitopes (36), (33), (13), (8), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1)
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