Integrin beta 3 (ITGB3) antibody

Details for Product No. ABIN118758
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Antigen
Synonyms BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT, INGRB3, integrin
Reactivity
Human, Monkey
(309), (165), (80), (48), (43), (26), (26), (8), (4), (3), (1), (1), (1), (1), (1)
Host
Mouse
(175), (157), (49), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(54), (29), (23), (7), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB), Flow Cytometry (FACS)
(184), (176), (74), (67), (61), (50), (35), (34), (16), (12), (8), (2), (1)
Pubmed 3 references available
Catalog no. ABIN118758
Quantity 0.2 mg
Price
500.50 $   Plus shipping costs $45.00
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Platelet plasma membrane.
Clone PM6-13
Isotype IgG1
Specificity This antibody recognises a 105 kD glycoprotein, which is the Integrin beta 3 chain.
Purification Protein A affinity chromatography
Alternative Name CD61 / ITGB3
Background Integrin beta 3 chain associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) at the cell surface. CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51. CD61 is a receptor for fibrinogen, fibronectin, vWF, vitronectin and thrombospondin.
Alternate names: GP3A, GPIIIa, Integrin beta-3, Platelet membrane glycoprotein IIIa
NCBI Accession 9606
UniProt P05106
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow cytometry (use 10 ul of 1/100 - 1/200 diluted antibody to label 10e6 cells or 100 ul of whole blood). Immunohistochemistry on frozen sections (Recommended positive control tissue: Bone marrow). Immunoprecipitation. Western Blot (Non-reducing conditions). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This antibody inhibits platelet aggregation and activation induced by thrombin and collagen.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4, with 0.09% sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. Dilute only prior to immediate use
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C or below for longer.
Expiry Date 12 months
Background publications Hynes: "Integrins: versatility, modulation, and signaling in cell adhesion." in: Cell, Vol. 69, Issue 1, pp. 11-25, 1992 (PubMed).

Phillips, Charo, Scarborough: "GPIIb-IIIa: the responsive integrin." in: Cell, Vol. 65, Issue 3, pp. 359-62, 1991 (PubMed).

General Michelson, Page, Casey et al.: "An eosinophilia-myalgia syndrome related disorder associated with exposure to L-5-hydroxytryptophan." in: The Journal of rheumatology, Vol. 21, Issue 12, pp. 2261-5, 1995 (PubMed).

Hosts (175), (157), (49), (2), (1)
Reactivities (309), (165), (80), (48), (43), (26), (26), (8), (4), (3), (1), (1), (1), (1), (1)
Applications (184), (176), (74), (67), (61), (50), (35), (34), (16), (12), (8), (2), (1)
Conjugates (54), (29), (23), (7), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1), (1), (1), (1)
Epitopes (37), (36), (14), (11), (4), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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