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Integrin beta 3 antibody (ITGB3)

Details for Product anti-ITGB3 Antibody No. ABIN118758, Supplier: Login to see
Antigen
  • CD61
  • GP3A
  • INGRB3
  • BDPLT16
  • BDPLT2
  • GPIIIa
  • GT
  • INTB3
  • integrin
  • GPIIIA
Reactivity
Human, Monkey
426
180
116
19
19
13
13
10
8
7
5
5
5
4
3
3
3
2
2
1
1
Host
Mouse
246
208
72
7
2
2
Clonality (Clone)
Monoclonal ()
Conjugate
This Integrin beta 3 antibody is un-conjugated
80
52
23
10
9
5
4
4
3
2
2
2
2
2
2
2
Application
Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB)
282
234
108
70
67
61
60
24
23
11
11
11
6
5
5
5
4
4
2
2
2
2
Supplier
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Immunogen Platelet plasma membrane.
Clone PM6-13
Isotype IgG1
Purification Protein A affinity chromatography
Alternative Name CD61 / ITGB3 (ITGB3 Antibody Abstract)
Background Integrin beta 3 chain associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) at the cell surface. CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51. CD61 is a receptor for fibrinogen, fibronectin, vWF, vitronectin and thrombospondin.Synonyms: GP3A, GPIIIa, Integrin beta-3, Platelet membrane glycoprotein IIIa
Gene ID 9606
UniProt P05106
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways
Application Notes Flow cytometry (use 10 μL of 1/100 - 1/200 diluted antibody to label 10^6 cells or 100 μL of whole blood). Immunohistochemistry on frozen sections (Recommended positive control tissue: Bone marrow). Immunoprecipitation. Western Blot (Non-reducing conditions).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This antibody inhibits platelet aggregation and activation induced by thrombin and collagen.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4, with 0.09 % sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. Dilute only prior to immediate use
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C or below for longer.
Background publications Michelson, Page, Casey et al.: "An eosinophilia-myalgia syndrome related disorder associated with exposure to L-5-hydroxytryptophan." in: The Journal of rheumatology, Vol. 21, Issue 12, pp. 2261-5, 1995 (PubMed).

Phillips, Charo, Scarborough: "GPIIb-IIIa: the responsive integrin." in: Cell, Vol. 65, Issue 3, pp. 359-62, 1991 (PubMed).

Hynes: "Integrins: versatility, modulation, and signaling in cell adhesion." in: Cell, Vol. 69, Issue 1, pp. 11-25, 1992 (PubMed).