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Integrin beta 3 antibody (ITGB3)

Details for Product anti-ITGB3 Antibody No. ABIN118759, Supplier: Log in to see
Antigen
  • CD61
  • GP3A
  • INGRB3
  • BDPLT16
  • BDPLT2
  • GPIIIa
  • GT
  • INTB3
  • integrin
  • GPIIIA
  • integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
  • integrin beta 3
  • integrin, beta 3
  • ITGB3
  • Itgb3
Reactivity
Human, Monkey
579
243
206
27
27
27
25
18
15
12
9
7
7
7
5
3
2
2
2
2
1
1
1
1
1
1
Host
Mouse
369
226
59
29
12
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Integrin beta 3 antibody is un-conjugated
84
56
29
18
14
12
10
10
9
9
9
7
7
7
7
6
6
6
5
4
4
4
2
2
2
2
2
2
2
Application
Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB)
420
274
164
126
105
87
85
77
64
27
13
13
8
6
6
6
5
5
4
4
2
2
2
2
1
1
1
Options
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Immunogen Platelet plasma membrane. Spleen cells from immunised BALB/c mice were fused with cells from the SP2/0 mouse myeloma cell line.
Clone PM6-13
Isotype IgG1
Purification Affinity chromatography on Protein A
Alternative Name CD61 / ITGB3 (ITGB3 Antibody Abstract)
Background CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51. CD61 is a receptor for fibrinogen, fibronectin, vWF, vitronectin and thrombospondin. This clone inhibits platelet aggregation and activation induced by thrombin and collagen.Synonyms: GP3A, GPIIIa, Integrin beta-3, Platelet membrane glycoprotein IIIa
Gene ID 9606
UniProt P05106
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow cytometry: 1/100 - 1/200, use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL. Immunoprecipitation. Western Blot. Immunohistochemistry on frozen sections. Recommended positive control tissue: Bone marrow. Removal of sodium azide is recommended prior to use in functional assays.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Michelson, Page, Casey, Trucksess, Love, Milstien, Wilson, Massaquoi, Crofford, Hallett: "An eosinophilia-myalgia syndrome related disorder associated with exposure to L-5-hydroxytryptophan." in: The Journal of rheumatology, Vol. 21, Issue 12, pp. 2261-5, 1995 (PubMed).

Hynes: "Integrins: versatility, modulation, and signaling in cell adhesion." in: Cell, Vol. 69, Issue 1, pp. 11-25, 1992 (PubMed).

Phillips, Charo, Scarborough: "GPIIb-IIIa: the responsive integrin." in: Cell, Vol. 65, Issue 3, pp. 359-62, 1991 (PubMed).