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Details for Product No. ABIN118759

Integrin beta 3 (ITGB3) antibody

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Antigen
Synonyms BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT, INGRB3, integrin
Reactivity
»Alternatives Human, Monkey
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB), Flow Cytometry (FACS)
Pubmed 3 references available
Catalog no. ABIN118759
Quantity 0.1 mg
Price
242.00 $   Plus shipping costs $45.00
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Immunogen Platelet plasma membrane. Spleen cells from immunised BALB/c mice were fused with cells from the SP2/0 mouse myeloma cell line.
Clone PM6-13
Isotype IgG1
Specificity This antibody recognises CD61, a 105kD glycoprotein, which is also known as integrin beta 3 chain. This molecule associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) at the cell surface.
Purification Affinity chromatography on Protein A
Alternative Name CD61 / ITGB3
Background CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51. CD61 is a receptor for fibrinogen, fibronectin, vWF, vitronectin and thrombospondin. This clone inhibits platelet aggregation and activation induced by thrombin and collagen.
Alternate names: GP3A, GPIIIa, Integrin beta-3, Platelet membrane glycoprotein IIIa
NCBI Accession 9606
UniProt P05106
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow cytometry: 1/100 - 1/200, use 10 ul of the suggested working dilution to label 10e6 cells in 100ul. Immunoprecipitation. Western Blot. Immunohistochemistry on frozen sections. Recommended positive control tissue: Bone marrow. Removal of sodium azide is recommended prior to use in functional assays. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH7.4 containing 0.09% Sodium Azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Phillips, Charo, Scarborough: "GPIIb-IIIa: the responsive integrin." in: Cell, Vol. 65, Issue 3, pp. 359-62, 1991 (PubMed).

Hynes: "Integrins: versatility, modulation, and signaling in cell adhesion." in: Cell, Vol. 69, Issue 1, pp. 11-25, 1992 (PubMed).

Michelson, Page, Casey et al.: "An eosinophilia-myalgia syndrome related disorder associated with exposure to L-5-hydroxytryptophan." in: The Journal of rheumatology, Vol. 21, Issue 12, pp. 2261-5, 1995 (PubMed).

Alternatives for antigen "Integrin beta 3 (ITGB3)", type "Antibodies"
Hosts (164), (159), (41), (2), (1)
Reactivities (301), (150), (81), (48), (45), (27), (26), (8), (8), (3), (2), (1), (1), (1), (1)
Applications (182), (158), (75), (57), (49), (41), (34), (30), (17), (14), (14), (4), (3), (2), (1)
Conjugates (54), (28), (22), (7), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (1), (1), (1), (1), (1)
Epitopes (36), (33), (13), (8), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1)
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