Integrin beta 3 (ITGB3) antibody

Details for Product No. ABIN118759
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Antigen
Synonyms CD61, GP3A, INGRB3, BDPLT16, BDPLT2, GPIIIa, GT, INTB3, integrin, GPIIIA
Reactivity
Human, Monkey
(304), (164), (86), (48), (43), (26), (24), (8), (4), (3), (1), (1), (1), (1)
Host
Mouse
(169), (155), (49), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(54), (27), (22), (9), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB), Flow Cytometry (FACS)
(184), (173), (67), (67), (52), (51), (35), (30), (13), (12), (10), (8), (2), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

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Catalog No. ABIN118759
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Immunogen Platelet plasma membrane. Spleen cells from immunised BALB/c mice were fused with cells from the SP2/0 mouse myeloma cell line.
Clone PM6-13
Isotype IgG1
Specificity This antibody recognises CD61, a 105kD glycoprotein, which is also known as integrin beta 3 chain. This molecule associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) at the cell surface.
Purification Affinity chromatography on Protein A
Alternative Name CD61 / ITGB3
Background CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51. CD61 is a receptor for fibrinogen, fibronectin, vWF, vitronectin and thrombospondin. This clone inhibits platelet aggregation and activation induced by thrombin and collagen.
Alternate names: GP3A, GPIIIa, Integrin beta-3, Platelet membrane glycoprotein IIIa
Gene ID 9606
UniProt P05106
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow cytometry: 1/100 - 1/200, use 10 ul of the suggested working dilution to label 10e6 cells in 100ul. Immunoprecipitation. Western Blot. Immunohistochemistry on frozen sections. Recommended positive control tissue: Bone marrow. Removal of sodium azide is recommended prior to use in functional assays. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH7.4 containing 0.09% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Phillips, Charo, Scarborough: "GPIIb-IIIa: the responsive integrin." in: Cell, Vol. 65, Issue 3, pp. 359-62, 1991 (PubMed).

General Hynes: "Integrins: versatility, modulation, and signaling in cell adhesion." in: Cell, Vol. 69, Issue 1, pp. 11-25, 1992 (PubMed).

Michelson, Page, Casey et al.: "An eosinophilia-myalgia syndrome related disorder associated with exposure to L-5-hydroxytryptophan." in: The Journal of rheumatology, Vol. 21, Issue 12, pp. 2261-5, 1995 (PubMed).

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