Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

CD72 antibody

CD72 Reactivity: Human FACS, IP Host: Mouse Monoclonal 3F3 unconjugated
Catalog No. ABIN118793
  • Target See all CD72 Antibodies
    CD72 (CD72 Molecule (CD72))
    Reactivity
    • 46
    • 19
    • 1
    Human
    Host
    • 37
    • 20
    • 1
    Mouse
    Clonality
    • 37
    • 21
    Monoclonal
    Conjugate
    • 26
    • 7
    • 7
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD72 antibody is un-conjugated
    Application
    • 29
    • 24
    • 22
    • 8
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP)
    Specificity
    The antibody reacts with CD72, a 39-43 kDa type II membrane glycoprotein (C-type lectin family).
    Purification
    Precipitation methods and ion exchange chromatography
    Purity
    > 95 % (by SDS-PAGE)
    Immunogen
    Normal human lymphocytes from a lymph node
    Clone
    3F3
    Isotype
    IgG2b
    Top Product
    Discover our top product CD72 Primary Antibody
  • Application Notes
    Immunoprecipitation. Flow Cytometry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing. Dilute only prior to immediate use
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody (undiluted) at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    CD72 (CD72 Molecule (CD72))
    Alternative Name
    CD72 (CD72 Products)
    Synonyms
    CD72c antibody, Ly-19 antibody, Ly-32 antibody, Ly-m19 antibody, Lyb-2 antibody, CD72b antibody, LYB2 antibody, CD72 antigen antibody, CD72 molecule antibody, Cd72 antibody, CD72 antibody
    Background
    CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation. CD72 is a pan-B cell marker expressed throughout the B lymphocytes diferentiation with the exception of plasma cells, it is also present on follicular dendritic cells.Synonyms: B-Cell marker, B-cell differentiation antigen CD72, Ly-32, Ly32, Lyb-2, Lymphocyte antigen 32
    Gene ID
    971
    NCBI Accession
    NP_001773
    UniProt
    P21854
    Pathways
    BCR Signaling
You are here:
Support