Myelin Basic Protein (MBP) (AA 84-89) antibody

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Antigen
  • cb274
  • fj33b11
  • mbp
  • wu:fj33b11
  • wu:fq15b02
  • zgc:136630
  • MGC115135
  • Mbps
  • C76307
  • Hmbpr
  • R75289
  • golli-mbp
  • mld
  • shi
  • myelin basic protein a
  • myelin basic protein
  • mbpa
  • mbp
  • MBP
  • Mbp
Epitope
AA 84-89
12
10
7
6
6
6
5
5
4
4
4
4
4
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mammalian
156
50
42
40
14
14
13
11
5
5
5
4
4
4
3
2
2
1
Host
Mouse
90
69
15
9
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
5
5
4
3
3
2
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
122
78
63
41
30
25
24
14
12
7
7
6
6
4
3
3
1
Options
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Immunogen Human myelin basic protein. Spleen cells from immunised mice were fused with cells of the mouse SP2/0 myeloma cell line.
Clone 22
Isotype IgG2b
Specificity This antibody recognises an epitope of Human myelin basic protein between amino acids 84-89. Reacts with MBP from most species.
Purification Supernatant
Alternative Name Myelin Basic Protein (MBP Antibody Abstract)
Background The classic group of Myelin basic protein (MBP) isoforms (isoforms 4 to 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non classic group of MBP isoforms (isoforms 1 to 3/Golli MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T cells and neural cells. Differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function.Synonyms: MBP, Myelin membrane encephalitogenic protein
Gene ID 4155
NCBI Accession NP_001020252
UniProt P02686
Research Area Glia marker, Cell/Tissue Markers
Application Notes Immunohistochemistry on frozen sections. Immunohistochemistry on paraffin sections. Recommended positive control: Brain. Has been reported to work in Western blotting.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (IHC) image for anti-Myelin Basic Protein (MBP) (AA 84-89) antibody (ABIN119023) Staining of white matter in human brain with Mouse anti MBP
Background publications Liao, Ahmed, Smith, Van Nostrand: "Degradation of amyloid beta protein by purified myelin basic protein." in: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 28917-25, 2009 (PubMed).

Harrower, Tyers, Hooks, Barker: "Long-term survival and integration of porcine expanded neural precursor cell grafts in a rat model of Parkinson's disease." in: Experimental neurology, Vol. 197, Issue 1, pp. 56-69, 2005 (PubMed).

Groome, Dawkes, Barry, Hruby, Alvord: "New monoclonal antibodies reactive with defined sequential epitopes in human myelin basic protein." in: Journal of neuroimmunology, Vol. 19, Issue 4, pp. 305-15, 1988 (PubMed).