Vesicle-Associated Membrane Protein 1 (Synaptobrevin 1) (VAMP1) antibody

Details for Product No. ABIN119028
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Antigen
Synonyms SYB1, VAMP-1, syb1, vamp-1, Syb1, lew, Syb-1, VAMP1, An12g07570
Reactivity
Human, Pig (Porcine)
(44), (25), (21), (17), (15), (13), (12), (12), (5), (1), (1)
Host
Mouse
(38), (20), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(46), (18), (16), (10), (10), (8), (6), (1)
Pubmed 9 references available
Catalog no. ABIN119028
Quantity 0.2 mg
Price
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Immunogen Crude human synaptic immunoprecipitate. Spleen cells from immunised BALB/c mice were fused with cells of the NSO myeloma cell line.
Clone SP11
Isotype IgG1
Specificity This antibody appears to recognise the synaptic vesicle protein synaptobrevin, VAMP, (3., 6.).
Purification Affinity chromatography on Protein G
Alternative Name VAMP-1 / Synaptobrevin-1
Background Alternate names: SYB1, VAMP1, Vesicle-associated membrane protein 1
Gene ID 6843
NCBI Accession NP_055046.1
UniProt P23763
Application Notes ELISA. Western Blot: 1/1000. Immunohistochemistry on paraffin sections: This product does not require protein digestion pre-treatment of paraffin sections, This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections. Recommended Positive Control: Brain. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH7.2 containing 0.09% Sodium Azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Vesicle-Associated Membrane Protein 1 (Synaptobrevin 1) (VAMP1) antibody Western blot analysis of human brain extract probed with MOUSE ANTI HUMAN
Background publications Honer, Beach, Hu et al.: "Hippocampal synaptic pathology in patients with temporal lobe epilepsy." in: Acta neuropathologica, Vol. 87, Issue 2, pp. 202-10, 1994 (PubMed).

General Honer, Dickson, Gleeson et al.: "Regional synaptic pathology in Alzheimer's disease." in: Neurobiology of aging, Vol. 13, Issue 3, pp. 375-82, 1992 (PubMed).

Honer, Kaufmann, Davies: "Characterization of a synaptic antigen of interest in neuropsychiatric illness." in: Biological psychiatry, Vol. 31, Issue 2, pp. 147-58, 1992 (PubMed).

Honer, Kaufmann, Kleinman et al.: "Monoclonal antibodies to study the brain in schizophrenia." in: Brain research, Vol. 500, Issue 1-2, pp. 379-83, 1990 (PubMed).

Honer, Hu, Davies: "Human synaptic proteins with a heterogeneous distribution in cerebellum and visual cortex." in: Brain research, Vol. 609, Issue 1-2, pp. 9-20, 1993 (PubMed).

Dickson, Davies, Bevona et al.: "Hippocampal sclerosis: a common pathological feature of dementia in very old (> or = 80 years of age) humans." in: Acta neuropathologica, Vol. 88, Issue 3, pp. 212-21, 1995 (PubMed).

Wakabayashi, Honer, Masliah: "Synapse alterations in the hippocampal-entorhinal formation in Alzheimer's disease with and without Lewy body disease." in: Brain research, Vol. 667, Issue 1, pp. 24-32, 1995 (PubMed).

Masliah, Honer, Mallory et al.: "Topographical distribution of synaptic-associated proteins in the neuritic plaques of Alzheimer's disease hippocampus." in: Acta neuropathologica, Vol. 87, Issue 2, pp. 135-42, 1994 (PubMed).

Simpson, Chundu, Davies-Hill et al.: "Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease." in: Annals of neurology, Vol. 35, Issue 5, pp. 546-51, 1994 (PubMed).

Hosts (38), (20), (2), (1)
Reactivities (44), (25), (21), (17), (15), (13), (12), (12), (5), (1), (1)
Applications (46), (18), (16), (10), (10), (8), (6), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (2), (2), (2), (2), (2), (1), (1), (1), (1)
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