anti-Cyclin D2 antibody (CCND2)

Details for Product anti-CCND2 Antibody No. ABIN119185
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Antigen
Reactivity
Human
(172), (65), (47), (1), (1)
Host
Mouse
(104), (75)
Clonality (Clone)
Monoclonal ()
Conjugate
This Cyclin D2 antibody is un-conjugated
(5), (5), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro))
(150), (51), (40), (34), (21), (18), (17), (10), (10), (9), (8), (6), (5), (5), (3), (3), (1), (1), (1), (1)
Pubmed 2 references available
Quantity 1 mL
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Immunogen Prokaryotic recombinant protein corresponding to full length cyclin D2.
Clone DCS-3-1
Isotype IgG2a
Specificity This antibody is specific to cyclin D2.
Cellular Localization: Nuclear
Purification Ig Fraction
Alternative Name Cyclin D2 (CCND2 Antibody Abstract)
Background Overexpession of cyclin D2 leads to acceleration of the G1 phase. The expression of cyclin D2 protein is more restricted than that of cyclin D1.Synonyms: CCND2, Cyclin-D2
Gene ID 894
NCBI Accession NP_001750
UniProt P30279
Research Area Cancer, Cell Cycle
Application Notes Immunohistochemistry on frozen sections: diluted of 1:25-1:50 in an ABC method (30-60 minutes at room temperature) Recommended Positive Control: Breast carcinoma
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer containing sodium azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Lukas, Bartkova, Welcker et al.: "Cyclin D2 is a moderately oscillating nucleoprotein required for G1 phase progression in specific cell types." in: Oncogene, Vol. 10, Issue 11, pp. 2125-34, 1995 (PubMed).

General Bartkova, Lukas, Müller et al.: "Abnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancer." in: Cancer research, Vol. 55, Issue 4, pp. 949-56, 1995 (PubMed).

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Catalog No. ABIN119185
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