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Estrogen Receptor 2 (ER Beta) (ESR2) (C-Term), (Isoform 1) antibody

Details for Product No. ABIN119336, Supplier: Login to see
Antigen
  • ER[b]1
  • zfER-beta1
  • zfER[b]1
  • erb
  • esrb
  • estrb
  • nr3a2
  • ERbeta
  • er-beta
  • esr-beta
  • ESR2
  • er
  • esr2
  • erb2
  • erb1
  • ER-beta
  • ER[b]
  • Estrb
  • ER-BETA
  • ESR-BETA
  • ESRB
  • ESTRB
  • Erb
  • NR3A2
  • Erb2
  • ERB
  • ERBETA
  • CERB
  • ERBeta2
  • erbeta
  • Esr2
Alternatives
anti-Human Estrogen Receptor 2 (ER Beta) antibody for Immunofluorescence
Epitope
C-Term, Isoform 1
66
33
27
22
18
18
17
15
14
14
13
13
11
6
6
5
5
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
329
97
81
9
9
8
8
4
2
2
1
1
Host
Mouse
265
68
15
5
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
19
18
15
11
9
9
3
3
3
3
3
3
3
3
3
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
255
132
50
41
39
34
25
18
12
10
8
4
3
3
3
3
1
Supplier
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Immunogen Synthetic peptide derived from the C-terminus of the Human oestrogen receptor beta 1 isoform. Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line.
Sequence CEDSKSKEGS QNPQSQ
Clone PPG5-10
Isotype IgG2a
Specificity This antibody recognises the Estrogen Receptor beta 1 isoform. The antibody has been used for the Immunohistochemical study of the expression of this isoform, showing positive nuclear staining in cells within the ovary, uterus, oviduct, breast, testis, prostate, bladder and male reproductive ducts.
Purification Supernatant
Alternative Name Estrogen Receptor beta (ESR2 Antibody Abstract)
Background Estrogen Receptor beta is a recent discovery, initially cloned and characterized from testis. Estrogen Receptor beta is highly homologous to Estrogen Receptor alpha, the ligand and DNA binding domains are highly conserved, while the amino terminus (transactivation domain), has diverged significantly. Estrogen Receptor beta binds estrogen with high affinity and regulates estrogen specific gene activation through direct interaction with estrogen response elements (EREs).Synonyms: ER-beta, ESR2, ESTRB, NR3A2, Nuclear receptor subfamily 3 group A member 2
Gene ID 2100
NCBI Accession NP_001035365
UniProt Q92731
Research Area Cancer, Endocrine system, Transcription Factors, Hormones, Receptors
Pathways Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway
Application Notes Immunohistochemistry on frozen sections. Immunohistochemistry on paraffin sections: 1/5 - 1/50, this product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Recommended Positive Control: Ovary.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-Estrogen Receptor 2 (ER Beta) (ESR2) (C-Term), (Isoform 1) antibody (ABIN119336) Photomicrograph of human ovary immunostained for estrogen receptor beta using antibod...
Background publications Marotti, Collins, Hu et al.: "Estrogen receptor-beta expression in invasive breast cancer in relation to molecular phenotype: results from the Nurses' Health Study." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 23, Issue 2, pp. 197-204, 2010 (PubMed).

Collins, MacPherson, Brown et al.: "Expression of oestrogen receptors, ERalpha, ERbeta, and ERbeta variants, in endometrial cancers and evidence that prostaglandin F may play a role in regulating expression of ERalpha." in: BMC cancer, Vol. 9, pp. 330, 2009 (PubMed).

Bianchi, Sahlin, Meikle et al.: "Endometrial population of oestrogen receptors alpha and beta and progesterone receptors A and B during the different phases of the follicular wave of llamas (Lama glama)." in: Reproduction in domestic animals = Zuchthygiene, Vol. 45, Issue 5, pp. 872-80, 2011 (PubMed).

Carpino, Rago, Pezzi et al.: "Detection of aromatase and estrogen receptors (ERalpha, ERbeta1, ERbeta2) in human Leydig cell tumor." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 157, Issue 2, pp. 239-44, 2007 (PubMed).

Wood, Usborne, Starost et al.: "Hyperplastic and neoplastic lesions of the mammary gland in macaques." in: Veterinary pathology, Vol. 43, Issue 4, pp. 471-83, 2006 (PubMed).

Juengel, Heath, Quirke et al.: "Oestrogen receptor alpha and beta, androgen receptor and progesterone receptor mRNA and protein localisation within the developing ovary and in small growing follicles of sheep." in: Reproduction (Cambridge, England), Vol. 131, Issue 1, pp. 81-92, 2006 (PubMed).

Wong, Malcomson, Jodrell et al.: "ERbeta isoform expression in colorectal carcinoma: an in vivo and in vitro study of clinicopathological and molecular correlates." in: The Journal of pathology, Vol. 207, Issue 1, pp. 53-60, 2005 (PubMed).

Fixemer, Remberger, Bonkhoff: "Differential expression of the estrogen receptor beta (ERbeta) in human prostate tissue, premalignant changes, and in primary, metastatic, and recurrent prostatic adenocarcinoma." in: The Prostate, Vol. 54, Issue 2, pp. 79-87, 2002 (PubMed).

Torlakovic, Lilleby, Torlakovic et al.: "Prostate carcinoma expression of estrogen receptor-beta as detected by PPG5/10 antibody has positive association with primary Gleason grade and Gleason score." in: Human pathology, Vol. 33, Issue 6, pp. 646-51, 2002 (PubMed).

Saunders, Millar, Williams et al.: "Expression of oestrogen receptor beta (ERbeta1) protein in human breast cancer biopsies." in: British journal of cancer, Vol. 86, Issue 2, pp. 250-6, 2002 (PubMed).

Saunders, Millar, Williams et al.: "Differential expression of estrogen receptor-alpha and -beta and androgen receptor in the ovaries of marmosets and humans." in: Biology of reproduction, Vol. 63, Issue 4, pp. 1098-105, 2000 (PubMed).

Moore, McKee, Slentz-Kesler et al.: "Cloning and characterization of human estrogen receptor beta isoforms." in: Biochemical and biophysical research communications, Vol. 247, Issue 1, pp. 75-8, 1998 (PubMed).