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Estrogen Receptor 1 (ESR1) antibody

Details for Product No. ABIN119395
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Antigen
Synonyms
ER, ERa, ESR, Estr, ER[a], Estra, Nr3a1, ERalpha, AA420328, AU041214, ER-alpha, ESRA, ESTRR, Era, NR3A1, Esr, RNESTROR, ERALPHA, ACTGP1, ACT1GP1, HY-psi-gamma-AC6, eralpha, zfER[a], ER[b]1, zfER-beta1 ... show more
ER, ERa, ESR, Estr, ER[a], Estra, Nr3a1, ERalpha, AA420328, AU041214, ER-alpha, ESRA, ESTRR, Era, NR3A1, Esr, RNESTROR, ERALPHA, ACTGP1, ACT1GP1, HY-psi-gamma-AC6, eralpha, zfER[a], ER[b]1, zfER-beta1, zfER[b]1, ER[b]2, ER[b]a, zfER[b]2, zfER-beta2, erb, esrb, estrb, nr3a2, ERbeta, er-beta, esr-beta, XER, era, esr, esra, nr3a1, xesr-1, xlERalpha1, xlERalpha2, LOC398733, LOC398734, err1, erra, esrral, erralpha, ESR2, ESRRA, ESR1, esrl1, nr3b1, er, LOC100125507 show less
Reactivity
Human
(608), (256), (143), (56), (39), (26), (13), (11), (3), (2), (1), (1), (1), (1), (1)
Host
Mouse
(488), (159), (7), (2), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(22), (18), (17), (10), (10), (10), (10), (10), (10), (10), (10), (7), (7), (7)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(469), (216), (196), (175), (100), (85), (67), (36), (26), (19), (10), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Pubmed 5 references available
Quantity 0.5 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN119395
665.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Prokaryotic recombinant protein corresponding to the full-length estrogen receptor molecule.
Clone 6F11
Isotype IgG1
Specificity This antibody is specific to estrogen receptor, which is associated with superior prognosis and a better response to endocrine therapy. Cellular Localization: Nuclear
Purification Supernatant
Alternative Name Estrogen receptor alpha
Background The nuclei of the estrogen receptor positive cells stain very strongly with this antibody, without any staining in the cytoplasm.
Alternate names: ER alpha, ESR, ESR1, Estradiol receptor, NR3A1, Nuclear receptor subfamily 3 group A member 1
Gene ID 2099
NCBI Accession NP_000116.2
UniProt P03372
Research Area Hormones, Receptors
Application Notes Immunoprecipitation: 1:50. Western Blot: 1:50 to 1:100. Immunohistochemistry on formalin-fixed paraffin embedded sections: diluted of 1:20 to 1:80 in an ABC method (30 minutes at room temperature) Recommended Positive Control: Breast carcinoma Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 10 mM citrate buffer, pH 6.0 - containing sodium azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Product cited in: Konwisorz, Springwald, Haselberger et al.: "Knockdown of ICB-1 gene enhanced estrogen responsiveness of ovarian and breast cancer cells." in: Endocrine-related cancer, Vol. 17, Issue 1, pp. 147-57, 2010 (PubMed).

General Bur, Zimarowski, Schnitt et al.: "Estrogen receptor immunohistochemistry in carcinoma in situ of the breast." in: Cancer, Vol. 69, Issue 5, pp. 1174-81, 1992 (PubMed).

Graham, Jin, Lloyd: "Detection of estrogen receptor in paraffin-embedded sections of breast carcinoma by immunohistochemistry and in situ hybridization." in: The American journal of surgical pathology, Vol. 15, Issue 5, pp. 475-85, 1991 (PubMed).

Pertschuk, Kim, Nayer et al.: "Immunocytochemical estrogen and progestin receptor assays in breast cancer with monoclonal antibodies. Histopathologic, demographic, and biochemical correlations and relationship to endocrine response and survival." in: Cancer, Vol. 66, Issue 8, pp. 1663-70, 1990 (PubMed).

Kumar, Green, Stack et al.: "Functional domains of the human estrogen receptor." in: Cell, Vol. 51, Issue 6, pp. 941-51, 1988 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN119395
665.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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