Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) antibody

Details for Product No. ABIN119541
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Antigen
Synonyms PTPRC, si:dkeyp-47c5.1, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, Cd45, Ly-5, Lyt-4, loc, Lca, RT7, cd45
Reactivity
Human
(664), (482), (138), (56), (40), (36), (31), (19), (17), (7), (5), (3), (3), (2), (2), (1), (1)
Host
Mouse
(686), (457), (146), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(186), (144), (125), (61), (19), (15), (12), (12), (10), (9), (8), (8), (8), (7), (6), (6), (6), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(1025), (215), (212), (210), (191), (150), (104), (100), (76), (40), (17), (8), (4), (2), (2), (2), (1), (1)
Pubmed 3 references available
Quantity 1 mg
Shipping to United States (Change)
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Catalog No. ABIN119541
1,094.50 $
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Immunogen Human T lymphocytes
Clone F8-11-13
Isotype IgG1
Specificity SM1796A recognises the CD45RA cell surface antigen. Clone F8-11-13 reacts with the high molecular weight form of the leucocyte common antigen (LCA) expressed by B lymphocytes and a subset of T lymphocytes.
Purification Protein G chromatography
Alternative Name CD45 / LCA
Background CD45 is a complex molecule existing in a number of isoforms. Antibodies recognising a common epitope on all of these isoforms are termed CD45 whilst those recognising only individual isoforms are termed CD45RA or CD45RO etc.
Alternate names: L-CA, Leukocyte common antigen, PTPRC, Receptor-type tyrosine-protein phosphatase C, T200
Gene ID 5788
NCBI Accession NP_002829
UniProt P08575
Application Notes Flow cytometry: this product is routinely tested on human peripheral blood lymphocytes. Use 10 ul of 1/50 - 1/100 diluted antibody to label 10e6 cells in 100 ul. Immunohistochemistry on frozen and paraffin embedded sections: this product does not require protein digestion pre-treatment of paraffin sections and it does not require antigen retrieval using heat treatment prior to staining of paraffin sections. Recommended positive control: human tonsil. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH 7.2, without preservatives or stabilizers
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody prior to reconstitution at -20°C. Following reconstitution the antibody can be stored at 2-8°C for one month or at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) antibody Staining of human peripheral blood lymphocytes with MOUSE ANTI HUMAN CD45RA:AZIDE FREE (ABIN119541).
Background publications Dalchau, Fabre: "Identification with a monoclonal antibody of a predominantly B lymphocyte-specific determinant of the human leukocyte common antigen. Evidence for structural and possible functional diversity of the human leukocyte common molecule." in: The Journal of experimental medicine, Vol. 153, Issue 4, pp. 753-65, 1981 (PubMed).

OGrady, Stewart, Lowrey et al.: "CD40 expression in Hodgkin's disease." in: The American journal of pathology, Vol. 144, Issue 1, pp. 21-6, 1994 (PubMed).

Franitza, Kollet, Brill et al.: "TGF-beta1 enhances SDF-1alpha-induced chemotaxis and homing of naive T cells by up-regulating CXCR4 expression and downstream cytoskeletal effector molecules." in: European journal of immunology, Vol. 32, Issue 1, pp. 193-202, 2001 (PubMed).

Validation Images
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