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CD45 antibody (Protein tyrosine Phosphatase, Receptor Type, C) (FITC)

Details for Product anti-PTPRC Antibody No. ABIN119543, Supplier: Log in to see
Antigen
  • PTPRC
  • si:dkeyp-47c5.1
  • B220
  • CD45
  • CD45R
  • GP180
  • L-CA
  • LCA
  • LY5
  • T200
  • Cd45
  • Ly-5
  • Lyt-4
  • loc
  • Lca
  • RT7
  • cd45
Reactivity
Human
923
604
185
69
48
41
38
27
21
11
8
5
5
4
3
3
2
1
1
1
1
1
Host
Mouse
959
632
201
2
2
Clonality (Clone)
Monoclonal ()
Conjugate
This CD45 antibody is conjugated to FITC
266
199
148
100
38
27
22
20
20
19
16
16
14
14
14
14
10
8
7
6
6
6
5
5
5
5
5
5
5
5
4
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
1418
316
308
269
211
194
174
110
65
47
40
29
26
12
11
10
7
7
6
6
4
4
2
2
2
2
2
2
2
2
1
1
1
1
1
Supplier
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Immunogen Human T lymphocytes. Spleen cells from immunised BALB/c mouse were fused with cells of the NS-1 mouse myeloma cell line.
Clone F8-11-13
Isotype IgG1
Specificity This antibody recognises the CD45RA cell surface antigen. Clone F8-11-13 reacts with the high molecular weight form of the leucocyte common antigen (LCA) expressed by B lymphocytes and a subset of T lymphocytes.
Purification Affinity chromotography on protein G
Alternative Name CD45 / LCA (PTPRC Antibody Abstract)
Background CD45 is a complex molecule existing in a number of isoforms. Antibodies recognising a common epitope on all of these isoforms are termed CD45 whilst those recognising only individual isoforms are termed CD45RA or CD45RO etc.Synonyms: L-CA, Leukocyte common antigen, PTPRC, Receptor-type tyrosine-protein phosphatase C, T200
Gene ID 5788
NCBI Accession NP_002829
UniProt P08575
Pathways
Application Notes Flow cytometry: Neat - 1/10, Use 10 μL of the suggested working dilution to label 100 μL lysed whole blood.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, pH 7.2 containing 0.09 % Sodium Azide and 1 % Bovine Serum Albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-CD45 antibody (Protein tyrosine Phosphatase, Receptor Type, C)  (FITC) (ABIN119543) Staining of human peripheral blood lymphocytes with MOUSE ANTI HUMAN CD45RA:FITC (ABI...
Background publications Franitza, Kollet, Brill et al.: "TGF-beta1 enhances SDF-1alpha-induced chemotaxis and homing of naive T cells by up-regulating CXCR4 expression and downstream cytoskeletal effector molecules." in: European journal of immunology, Vol. 32, Issue 1, pp. 193-202, 2001 (PubMed).

OGrady, Stewart, Lowrey et al.: "CD40 expression in Hodgkin's disease." in: The American journal of pathology, Vol. 144, Issue 1, pp. 21-6, 1994 (PubMed).

Dalchau, Kirkley, Fabre: "Monoclonal antibody to a human leukocyte-specific membrane glycoprotein probably homologous to the leukocyte-common (L-C) antigen of the rat." in: European journal of immunology, Vol. 10, Issue 10, pp. 737-44, 1981 (PubMed).

Dalchau, Fabre et al.: "Identification with a monoclonal antibody of a predominantly B lymphocyte-specific determinant of the human leukocyte common antigen. Evidence for structural and possible functional diversity of the ..." in: The Journal of experimental medicine, Vol. 153, Issue 4, pp. 753-65, 1981 (PubMed).