Integrin, alpha 5 (Fibronectin Receptor, alpha Polypeptide) (ITGA5) antibody

Details for Product No. ABIN119998
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Antigen
Synonyms ITGA5, Cd49e, Fnra, VLA5, CD49e, FNRA, VLA5A, Itga5_retired
Reactivity
Mouse (Murine)
(111), (107), (35), (13), (12), (3), (1)
Host
Rat
(62), (52), (45), (37), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(32), (19), (13), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func), Flow Cytometry (FACS)
(130), (71), (47), (40), (35), (27), (14), (13), (10), (10), (6), (1), (1), (1)
Pubmed 2 references available
Quantity 0.5 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN119998
632.50 $
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Immunogen Mouse MC/9 cell line. Spleen cells from immunised Lewis rats were fused with cells of the Murine P3X63Ag8.653
Clone MFR5 (5H10)
Isotype IgG2a
Specificity This antibody recognises integrin alpha 5 (CD49e), which associates with the beta 1 integrin (CD29) to form the fibronectin receptor CD49e/CD29 (VLA-5). Clone MFR5(5H10) has been reported to block CD49e mediated function.
Purification Affinity chromatography on Protein G
Endotoxin Level Low Endotoxin
Alternative Name CD49e / ITGA5
Background VLA-5 plays an important role in cell adhesion and migration and is expressed by mast cells, thymocytes, Tcells and monocytes.
Alternate names: CD49 antigen-like family member E, FNRA, Fibronectin receptor subunit alpha, Integrin alpha-5, Integrin alpha-F, VLA-5, VLA5
Gene ID 10090
UniProt P11688
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry: 1/10 - 1/25, Use 10ul of the suggested working dilution to label 10e6 cells in 100ml. Immunohistochemistry on frozen sections. Functional Assays. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: Endotoxin Level: less than 0.01 EU/ug
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH7.4
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody at -20 °C. Ship at 2 - 8 °C.
Expiry Date 12 months
Background publications Kinashi, Springer: "Adhesion molecules in hematopoietic cells." in: Blood cells, Vol. 20, Issue 1, pp. 25-44, 1995 (PubMed).

General Cukierman, Pankov, Stevens et al.: "Taking cell-matrix adhesions to the third dimension." in: Science (New York, N.Y.), Vol. 294, Issue 5547, pp. 1708-12, 2001 (PubMed).

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