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IL2 Receptor beta antibody

IL2RB Reactivity: Mouse FACS, IP, Func Host: Rat Monoclonal TM-BETA1 unconjugated
Catalog No. ABIN120200
  • Target See all IL2 Receptor beta (IL2RB) Antibodies
    IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))
    Reactivity
    • 92
    • 77
    • 16
    • 5
    • 1
    Mouse
    Host
    • 85
    • 25
    • 21
    Rat
    Clonality
    • 86
    • 44
    • 1
    Monoclonal
    Conjugate
    • 62
    • 10
    • 9
    • 7
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    This IL2 Receptor beta antibody is un-conjugated
    Application
    • 73
    • 55
    • 38
    • 26
    • 26
    • 17
    • 14
    • 10
    • 10
    • 8
    • 7
    • 7
    • 2
    • 2
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)
    Specificity
    This antibody recognises the CD122 cell surface glycoprotein. Clone TM-beta 1 is reported to block IL-2 high affinity binding to the IL-2R beta receptor. We recommend the use of SM2224LE for this purpose.
    Purification
    Affinity chromatography on Protein G
    Endotoxin Level
    Low Endotoxin
    Immunogen
    Cells from murine IL-2RB+ transformant TART-mBeta. Lymph node (cells from immunised Sprague Dawley rats were fused with cells of the mouse PA1 myeloma cell line.
    Clone
    TM-BETA1
    Isotype
    IgG2b
    Top Product
    Discover our top product IL2RB Primary Antibody
  • Application Notes
    Flow Cytometry: 1/10 - 1/50, Use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL. Immunoprecipitation. Functional Assays.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS, pH 7.4
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store the antibody at -20 °C to -70 °C.
  • Target
    IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))
    Alternative Name
    CD122 / IL2RB (IL2RB Products)
    Synonyms
    IL2RB antibody, il-2rb antibody, CD122 antibody, IL15RB antibody, P70-75 antibody, IL2RBC antibody, IL-15Rbeta antibody, IL15Rbeta antibody, Il-2/15Rbeta antibody, Il-2Rbeta antibody, p70 antibody, interleukin 2 receptor subunit beta antibody, interleukin-2 receptor subunit beta antibody, interleukin 2 receptor, beta antibody, interleukin 2 receptor, beta chain antibody, IL2RB antibody, LOC510185 antibody, il2rb antibody, Il2rb antibody
    Background
    CD122 is a 75-85kD molecule also known as interleukin-2 receptor (IL-2R) beta chain. In mouse, CD122 is primarily expressed on natural killer (NK) cells and at lower levels on lymphocyte subsets, monocytes and macrophages. CD122 can associate with the IL-2R alpha chain (CD25) and CD132 to form a functional high affinity receptor complex that binds IL-2. CD132/CD122 heterodimers can also be formed which bind IL-2 with intermediate affinity. IL-2 binding to the IL-2R is important in the generation and differentiation of T lymphocytes and NK cells.Synonyms: IL-2 receptor subunit beta, IL2 Receptor beta, Interleukin-2 receptor subunit beta, P70-75
    Gene ID
    16185
    NCBI Accession
    NP_032394
    UniProt
    P16297
    Pathways
    JAK-STAT Signaling, Growth Factor Binding
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