Chemokine (C-C Motif) Receptor 7 (CCR7) antibody (Biotin)

Antigen: Chemokine (C-C Motif) Receptor 7 (CCR7)

Synonyms: BLR2, EBI1, CD197, CDw197, CMKBR7, Ebi1h, Cdw197, Cmkbr7, MGC108519, CCR7, MGC165629, zgc:165629

Clonality: Monoclonal (4B12)

Host: Rat

Reactivity: Mouse (Murine)

Conjugate: Biotin

Application: Flow Cytometry (FACS)

Catalog no.: ABIN120209

Additional Information

Alternative name: CD197 / CCR7

Swiss-Prot: P47774

Immunogen: CCR7 rat basophilic leukaemia (RBL)-2H3 transfectants. Spleen cells from immunised Lou/c rats were fused with cells of the mouse X63.Ag8.653 myeloma cell line

Isotype: IgG2a

Clone: 4B12

Description: CD197 is a 43kD member of the G-protein coupled receptor family, which is commonly known as chemokine receptor 7 (CCR7). In mice, CD197 is expressed on most naive T cells, a subset of memory T cells, B cells, mature dendritic cells, NK cells, a subset of thymocytes and CD34+ macrophage progenitor cells. CD197 is a functional receptor for chemokines CCL21 and CCL19. The receptor plays an important role in regulating the trafficking and homing of lymphocytes and dendritic cells to secondary lymphoid organs. Alternate Names: CCR7.

Specificity: This antibody recognises CD197. Clone 4B12 does not block the binding of the ligand to CD197.

Application Details

Application Notes: Flow Cytometry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 0.1 mg/ml

Buffer: PBS, pH7.4 containing 0.09% Sodium Azide and 1% Bovine Serum Albumin

Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.

Research Area: CD Antigens, Surface Receptors of Immune Cells

Restrictions: For Research Use only