Integrin beta 3 antibody (ITGB3) (FITC)

Details for Product anti-ITGB3 Antibody No. ABIN120248, Supplier: Log in to see
Antigen
  • CD61
  • GP3A
  • INGRB3
  • BDPLT16
  • BDPLT2
  • GPIIIa
  • GT
  • INTB3
  • integrin
  • GPIIIA
  • integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
  • integrin beta 3
  • integrin, beta 3
  • ITGB3
  • Itgb3
Alternatives
anti-Human Integrin beta 3 antibody for Flow Cytometry
Reactivity
Mouse (Murine), Rat (Rattus)
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248
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24
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16
13
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1
Host
Hamster
378
238
51
29
28
4
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Integrin beta 3 antibody is conjugated to FITC
77
54
27
22
18
14
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10
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Application
Flow Cytometry (FACS)
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27
14
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13
8
6
5
5
4
2
2
2
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1
1
Options
Supplier
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Supplier Product No.
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Immunogen Mouse alpha 5 beta 3 protein purified from the mouse hybridoma 2B4. Spleen cells from immunised Armenian hamsters were fused with cells of the P3U1 mouse myeloma cell line.
Clone HM beta 3-1
Isotype IgG
Purification Affinity Chromatography on Protein G.
Alternative Name CD61 / ITGB3 (ITGB3 Antibody Abstract)
Background CD61 is a 90kD a type I membrane protein, which is expressed primarily on megakaryocytes, platelets, monocytes, macrophages, granulocytes and endothelial cells. CD61 associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) to form the platelet glycoprotein complex IIb/IIIa and the vitronectin receptor (VNR) respectively. The heterodimers formed with CD61 are receptors for a variety of ligands including fibrinogen, fibronectin, von Willebrands factor (vWF), vitronectin and thrombospondin.Synonyms: GP3A, GPIIIa, Integrin beta-3, Platelet membrane glycoprotein IIIa
Gene ID 10090
UniProt O54890
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex
Application Notes Flow Cytometry (Neat-1/10): Use 10 μL of of the suggested working dilution to label 10^6 cells in 100 μL. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-Integrin beta 3 (ITGB3) antibody (FITC) (ABIN120248) Staining of mouse peripheral blood platelets with HAMSTER ANTI MOUSE CD61:FITC
Background publications Yasuda, Hasunuma, Adachi, Sekine, Sakanishi, Hashimoto, Ra, Yagita, Okumura: "Expression and function of fibronectin binding integrins on rat mast cells." in: International immunology, Vol. 7, Issue 2, pp. 251-8, 1995 (PubMed).

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