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TNFSF18 antibody

TNFSF18 Reactivity: Mouse FACS Host: Rat Monoclonal YGL386 unconjugated
Catalog No. ABIN120289
  • Target See all TNFSF18 Antibodies
    TNFSF18 (Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18))
    Reactivity
    • 61
    • 30
    • 6
    • 2
    • 2
    • 1
    Mouse
    Host
    • 52
    • 10
    • 6
    Rat
    Clonality
    • 51
    • 15
    • 1
    Monoclonal
    Conjugate
    • 35
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TNFSF18 antibody is un-conjugated
    Application
    • 54
    • 32
    • 13
    • 13
    • 8
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Purification
    Affinity chromatography on Protein G
    Immunogen
    Recombinant mouse GITRL. Spleen cells from immunised DA rats were fused with cells of the Y3/Ag1.2.3 myeloma cell line.
    Clone
    YGL386
    Isotype
    IgG1
    Top Product
    Discover our top product TNFSF18 Primary Antibody
  • Application Notes
    Flow Cytometry: 1/25 - 1/50, use 10 μL of the suggested working dilution to label 106 cells in 100 μL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS, pH 7.4 containing 0.09 % Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    TNFSF18 (Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18))
    Alternative Name
    TNFSF18 / AITRL (TNFSF18 Products)
    Synonyms
    Gitrl antibody, AITRL antibody, GITRL antibody, TL6 antibody, hGITRL antibody, TNLG2A antibody, tumor necrosis factor (ligand) superfamily, member 18 antibody, TNF superfamily member 18 antibody, Tnfsf18 antibody, TNFSF18 antibody
    Background
    GITRL is a 20 kD member of the tumour necrosis factor ligand superfamily, otherwise known as TNSF18. Mouse GITRL is predominantly expressed on immature and mature dendritic cells, macrophages and B cells. Expression of mouse GITRL can be transiently up regulated on these cells, following lipolysaccharide (LPS) stimulation, but protein expression is rapidly down modulated shortly after stimulation. Studies demonstrate that GITRL can neutralise the suppressive effects of CD4+CD25+ regulatory T cells and can also provide a co-stimulatory signal for both naive and primed T cells, suggesting a key role for GITRL in the regulation of T cell-mediated immunity.Synonyms: AITRL, Activation-inducible TNF-related ligand, GITRL, Glucocorticoid-induced TNF-related ligand, TL6, Tumor necrosis factor ligand superfamily member 18, hGITRL
    Gene ID
    10090
    UniProt
    Q7TS55
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