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KLRK1 antibody

KLRK1 Reactivity: Human FACS, IP, IHC (fro) Host: Mouse Monoclonal 1D11 unconjugated
Catalog No. ABIN120294
  • Target See all KLRK1 Antibodies
    KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
    Reactivity
    • 54
    • 32
    • 8
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 54
    • 17
    • 3
    • 2
    • 2
    • 1
    Mouse
    Clonality
    • 53
    • 24
    • 2
    Monoclonal
    Conjugate
    • 34
    • 9
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This KLRK1 antibody is un-conjugated
    Application
    • 45
    • 43
    • 15
    • 14
    • 14
    • 13
    • 11
    • 11
    • 7
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    This antibody is specific for CD314, also known as natural killer receptor G2 (NKG2D) and as killer cell lectin-like receptor subfamily K, member 1 (KLRK1). Clone 1D11 is reported to inhibit T cell recognition of MICA (1,6). We recommend the use of SM2260LE for such studies.
    Purification
    Affinity Chromatography on Protein G.
    Immunogen
    NKL cells. Spleen cells from immunised RBF/DnJ mice were fused with cells of the p3 mouse myeloma cell line.
    Clone
    1D11
    Isotype
    IgG1
    Top Product
    Discover our top product KLRK1 Primary Antibody
  • Application Notes
    Flow Cytometry: Use 10 μL of 1/100 diluted antibody to label 106 cells in 100 μL. Immunoprecipitation. Immunohistochemistry on Frozen Sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
    Alternative Name
    CD314 / KLRK1 (KLRK1 Products)
    Synonyms
    KLRK1 antibody, NKG2D antibody, CD314 antibody, D12S2489E antibody, KLR antibody, NKG2-D antibody, D6H12S2489E antibody, Nkg2d antibody, Nkrp2 antibody, killer cell lectin like receptor K1 antibody, killer cell lectin-like receptor subfamily K, member 1 antibody, NKG2D protein antibody, KLRK1 antibody, Klrk1 antibody, NKG2D antibody
    Background
    CD314 is a C-type lectin-like activating receptor which is expressed on most natural killer (NK) cells, CD8 T cells and gamma delta T cells. CD314 forms homodimers that signal through an associated DAP10 adaptor protein. Ligands of CD314 include MICA, MICB and UL16 binding protein (ULBP), which are inducibly expressed. Ligand binding t °CD314 results in NK cell activation and potent costimulation of effector T cells.Synonyms: D12S2489E, Killer cell lectin-like receptor subfamily K member 1, NK cell receptor D, NKG2-D type II integral membrane protein, NKG2-D-activating NK receptor, NKG2D
    Gene ID
    100528032
    NCBI Accession
    NP_001186734
    UniProt
    P26718
    Pathways
    Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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