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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Notch 1 (NOTCH1) antibody (PE)
|Synonyms||hN1, TAN1, Mis6, Tan1, lin-12, 9930111A19Rik, NOTCH, NOTCH1, notch1, hn1, tan1, notch, xotch, xnotch, notch-1, xnotch1|
Human, Mouse (Murine)
Alternatives Flow Cytometry (FACS)
|4 references available|
|Quantity||100 tests (0.1 mg/ml) (Variants)|
|Price||269.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 6 to 8 Business Days|
|Immunogen||Synthetic peptide corresponding to cdc10-NCR region within mouse Notch1. Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line|
|Cross-Reactivity||Human, Mouse (Murine)|
|Description||Notch1 is a single transmembrane receptor which is expressed in a range of cells including hematopoietic cells in mouse fetal liver, adult thymus and bone marrow. Notch1 plays a role in embryonic development and tissue homeostasis in the adult. Recent work has suggested a further role for this receptor in the regulation of lymphopoieisis and myelopoiesis. Following ligand binding, Notch1 is cleaved in the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus, where it plays a role in the modulation of gene expression. Alternate Names: Notch1, NOTCH-1, TAN1, Neurogenic Locus Notch Homolog Protein 1, Translocation-associated Notch Protein TAN-1.|
|Application Notes||Flow Cytometry: Use 10 ul of Neat-1/10 diluted antibody to label 1x10e6 cells in 100 ul. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.|
|Buffer||PBS, pH 7.4, containing 0.09% Sodium Azide as preservative and 1% BSA as stabilizer.|
|Storage||Prior to and following reconstitution store the antibody at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Shelf Life: one year from despatch.Reconstitution: Restore with 1 ml distilled water..|
|Research Area||Receptors, Signaling, Inflammation, Immunology|
|Restrictions||For Research Use only|
|Staining of mouse thymus with Mouse anti NOTCH1-RPE (ABIN120355)|
Ray, Yao, Nowotny et al.: "Evidence for a physical interaction between presenilin and Notch." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 6, pp. 3263-8, 1999 (PubMed).
Huppert, Le, Schroeter et al.: "Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1." in: Nature, Vol. 405, Issue 6789, pp. 966-70, 2000 (PubMed).
Espinosa, Santos, Inglés-Esteve et al.: "p65-NFkappaB synergizes with Notch to activate transcription by triggering cytoplasmic translocation of the nuclear receptor corepressor N-CoR." in: Journal of cell science, Vol. 115, Issue Pt 6, pp. 1295-303, 2002 (PubMed).
Kang-Decker, Tong, Boussouar et al.: "Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency." in: Cancer cell, Vol. 5, Issue 2, pp. 177-89, 2004 (PubMed).