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Notch1 antibody (Notch 1) PE

Details for Product anti-NOTCH1 Antibody No. ABIN120355, Supplier: Login to see New
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Human, Mouse (Murine)
(215), (163), (63), (6), (2), (2), (2), (1), (1), (1)
(146), (140), (15), (8), (7), (2), (1)
Clonality (Clone)
Monoclonal ()
This Notch1 antibody is conjugated to PE
(26), (15), (13), (7), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Flow Cytometry (FACS)
(192), (101), (81), (79), (52), (37), (36), (16), (15), (5), (4), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1)
Pubmed 5 references available
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Quantity 100 tests
Shipping to United States ( )
Immunogen Synthetic peptide corresponding to cdc10-NCR region within mouse Notch1. Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line.
Clone MN1A
Isotype IgG1
Specificity This antibody is specific for Notch1.
Purification Affinity Chromatography on Protein G
Alternative Name NOTCH1 (NOTCH1 Antibody Abstract)
Background Notch1 is a single transmembrane receptor which is expressed in a range of cells including hematopoietic cells in mouse fetal liver, adult thymus and bone marrow. Notch1 plays a role in embryonic development and tissue homeostasis in the adult. Recent work has suggested a further role for this receptor in the regulation of lymphopoieisis and myelopoiesis. Following ligand binding, Notch1 is cleaved in the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus, where it plays a role in the modulation of gene expression.Synonyms: Neurogenic locus notch homolog protein 1, Notch 1, TAN1, hN1
Gene ID 4851
NCBI Accession NP_060087
UniProt P46531
Research Area Receptors, Signaling, Inflammation, Immunology
Pathways Notch Signaling
Application Notes Flow Cytometry: Use 10 μL of Neat-1/10 diluted antibody to label 1x10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with 1 mL distilled water.
Concentration 0.1 mg/mL
Buffer PBS, pH 7.4, containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Original vial: 1 year at 2-8 °C. After reconstitution, aliquot and freeze stock solution at -20 °C.
Expiry Date 12 months
Supplier Images
Flow Cytometry (FACS) image for anti-Notch1 antibody (Notch 1)  PE (ABIN120355) Staining of mouse thymus with Mouse anti NOTCH1-RPE (ABIN120355)
Background publications Dass, Choong: "Zoledronic acid inhibits osteosarcoma growth in an orthotopic model." in: Molecular cancer therapeutics, Vol. 6, Issue 12 Pt 1, pp. 3263-70, 2007 (PubMed).

Kang-Decker, Tong, Boussouar et al.: "Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency." in: Cancer cell, Vol. 5, Issue 2, pp. 177-89, 2004 (PubMed).

Espinosa, Santos, Inglés-Esteve et al.: "p65-NFkappaB synergizes with Notch to activate transcription by triggering cytoplasmic translocation of the nuclear receptor corepressor N-CoR." in: Journal of cell science, Vol. 115, Issue Pt 6, pp. 1295-303, 2002 (PubMed).

Huppert, Le, Schroeter et al.: "Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1." in: Nature, Vol. 405, Issue 6789, pp. 966-70, 2000 (PubMed).

Ray, Yao, Nowotny et al.: "Evidence for a physical interaction between presenilin and Notch." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 6, pp. 3263-8, 1999 (PubMed).

Catalog No. ABIN120355

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