SIT1 antibody (PE)

Catalog No. ABIN120659

Product Details anti-SIT1 Antibody (PE)

Target: SIT1 (Signaling threshold Regulating Transmembrane Adaptor 1 (SIT1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SIT1 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Specificity: The antibody reacts with SHP2-interacting transmembrane adaptor protein (SIT) expressed exclusively in lymphoid organs.

Characteristics: Synonyms: Signaling threshold-regulating transmembrane adapter 1, SHP2-interacting transmembraneadapter protein, Suppression-inducing transmembrane adapter 1

Immunogen: Bacterially produced recombinant intracellular fragment of human SIT

Clone: SIT-01

Isotype: IgG1

Application Details

Application Notes: Suitable for Flow cytometry (1/50, intracellular staining). Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2 % (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for SIT1

Target: SIT1 (Signaling threshold Regulating Transmembrane Adaptor 1 (SIT1))

Alternative Name: SIT1 / SIT (SIT1 Products)

Background: SIT (SHP2-interacting transmembrane adaptor protein) is expressed exclusively in lymphoid organs and acts either as a positive or as a negative regulatory element in T cell activation and in T cell development. Binding to Grb2 plays a pivotal role in signal transduction. Hubener et al. (2001) determined that the SIT gene contains 5 exons and spans 1.8 kb of genomic DNA. The SIT promoter demonstrated strong transcriptional activity and potential binding sites for both ubiquitous and lymphoid-specific transcription factors.Synonyms: SHP2-interacting transmembrane adapter protein, Signaling threshold-regulating transmembrane adapter 1, Suppression-inducing transmembrane adapter 1

Gene ID: 27240

UniProt: Q9Y3P8