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HLA-E antibody

HLA-E Reactivity: Human, Primate FACS, IP, IHC (p) Host: Mouse Monoclonal MEM-E-06 unconjugated
Catalog No. ABIN120711
  • Target See all HLA-E Antibodies
    HLA-E (HLA Class I Histocompatibility Antigen, alpha Chain E (HLA-E))
    Reactivity
    • 67
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Primate
    Host
    • 44
    • 24
    Mouse
    Clonality
    • 46
    • 22
    Monoclonal
    Conjugate
    • 31
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This HLA-E antibody is un-conjugated
    Application
    • 42
    • 27
    • 19
    • 13
    • 13
    • 12
    • 9
    • 7
    • 3
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    The antibody recognized native surface-expressed HLA-E, but not denaturated heavy chain of HLA-E. The published results showed that the antibody cross-reacts with some classical MHC Class I molecules (HLA-A3, -A11, -B7). However, the recent Workshop I Session on the 3rd International Conference on HLA-G (Paris, July 2003) confirmed that the antibody exhibits much broader cross-reactivity classical MHC Class I antigens, namely with HLA-A24, -A32, -B8, -B15, -B27, -B35, -B44, -B54, -C3, -C4, -C5, -C7.
    Purification
    Protein-A affinity chromatography
    Purity
    > 95 % pure (by SDS-PAGE)
    Immunogen
    Bacterially expressed recombinant HLA-E refolded with beta2-microglobulin and peptide
    Clone
    MEM-E-06
    Isotype
    IgG1
    Top Product
    Discover our top product HLA-E Primary Antibody
  • Application Notes
    Flow Cytometry. Immunoprecipitation.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Tris buffered saline (TBS) with 15 mM sodium azide, approx. pH 8.0
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
    Shelf Life: one year from despatch.
    Expiry Date
    12 months
  • Target
    HLA-E (HLA Class I Histocompatibility Antigen, alpha Chain E (HLA-E))
    Abstract
    HLA-E Products
    Synonyms
    EA1.2 antibody, EA2.1 antibody, HLA-6.2 antibody, MHC antibody, QA1 antibody, major histocompatibility complex, class I, E antibody, HLA-E antibody, PATR-E antibody
    Background
    HLA-E belongs to the MHC Class I molecules (MHC Class Ib, nonclassical) and it is expressed on many types of the human cells.Synonyms: HLA class I histocompatibility antigen, HLA-6.2, HLAE, MHC class I antigen E, alpha chain E
    Gene ID
    3133
    UniProt
    P13747
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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