TLR7 antibody (AA 451-500)

Catalog No. ABIN121174

Product Details anti-TLR7 Antibody

Target: TLR7 (Toll-Like Receptor 7 (TLR7))

Binding Specificity: AA 451-500

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TLR7 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: The antibody recognizes human TLR7. Other species not tested.

Purification: Protein-G affinity chromatography

Immunogen: Recombinant human TLR7 (451-500 aa) purified from E. coli

Clone: 4F4

Isotype: IgG1

Application Details

Application Notes: ELISA. Western blot (1:500 - 1:2,000), recommended starting dilution is 1:1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, containing 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.

Expiry Date: 12 months

Target Details for TLR7

Target: TLR7 (Toll-Like Receptor 7 (TLR7))

Alternative Name: TLR7 (TLR7 Products)

Synonyms: TLR7-like antibody, RGD1563357 antibody, toll like receptor 7 antibody, toll-like receptor 7 antibody, TLR7 antibody, Tlr7 antibody

Background: TLR7 is one of toll-like receptors which are type I transmembrane proteins involved in innate immunity by recognizing microbial conserved structures. These proteins are characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain, and act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. Human TLR7(hTLR7) is predominantly expressed in lung, placenta and spleen and hTLR7,8 genes are located on the sex chromosome X. hTLR7 may play an important role in detecting and combating viral infections.Synonyms: Toll-like receptor 7

Gene ID: 51284

UniProt: Q9NYK1

Pathways: TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades