Adiponectin, C1Q and Collagen Domain Containing (ADIPOQ) (AA 15-244) antibody

Details for Product No. ABIN121175
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Antigen
Synonyms MGC84292, ADIPOQ, APM1, ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, GBP28, 30kDa, APN, Acdc, Acrp30, adipo, apM1, ADN
Epitope
AA 15-244
(22), (16), (12), (6), (6), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(328), (119), (80), (22), (17), (14), (14), (2), (1)
Host
Mouse
(249), (154), (8), (7), (5)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(37), (18), (14), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(297), (251), (55), (47), (34), (22), (19), (11), (10), (10), (8), (7), (7), (4), (3), (2), (2), (2), (2), (1), (1)
Pubmed 4 references available
Quantity 0.1 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN121175
412.50 $
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Immunogen Recombinant human adiponectin (15-244 aa) purified from E. coli
Clone 1G12
Isotype IgG1
Specificity This antibody (1G12) has the specificity against globular domain of adiponectin.
Purification Protein-G affinity chromatography
Alternative Name Adiponectin
Background Human Adiponectin, also referred to as AdipoQ, Acrp30, apm-1 or GBP28, is a secreted protein expressed exclusively in differentiated adipocyte (adipokine). Adiponectin contains a modular structure comprising an N-terminal collagenous domain followed by a C-terminal globular domain (gAcrp30). Adiponectin plays a role in various physiological processes such as energy homeostasis and obesity. Plasma levels of adiponectin are reduced in obese humans, and decreased levels are associated with insulin resistance and hyperinsulinemia.Synonyms: 30 kDa adipocyte complement-related protein, ACDC, ACRP30, ADIPOQ, APM1, Adipocyte, Adipocyte complement-related 30 kDa protein, Adipose most abundant gene transcript 1 protein, C1q and collagen domain-containing protein, GBP28, Gelatin-binding protein
Gene ID 9370
UniProt Q15848
Research Area Cancer, Atherosclerosis, Metabolism, Hormones
Application Notes ELISA. Western blot (1:250 - 1:1,000), recommended starting dilution is 1:500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4, containing 0.02 % thimerosal
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.
Expiry Date 12 months
General Maeda, Okubo, Shimomura et al.: "cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1)." in: Biochemical and biophysical research communications, Vol. 221, Issue 2, pp. 286-9, 1996 (PubMed).

Berg, Combs, Du et al.: "The adipocyte-secreted protein Acrp30 enhances hepatic insulin action." in: Nature medicine, Vol. 7, Issue 8, pp. 947-53, 2001 (PubMed).

Berg, Combs, Scherer: "ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism." in: Trends in endocrinology and metabolism: TEM, Vol. 13, Issue 2, pp. 84-9, 2002 (PubMed).

Yamauchi, Kamon, Minokoshi et al.: "Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase." in: Nature medicine, Vol. 8, Issue 11, pp. 1288-95, 2002 (PubMed).

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