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Details for Product No. ABIN121206

Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3) (C-Term) antibody

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Synonyms A20, OTUD7C, TNFA1P2, Tnfip3, tnfaip3, MGC82339, TNFAIP3
»Alternatives C-Term
»Alternatives Human, Mouse (Murine), Rat (Rattus)
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN121206
Quantity 0.1 mg
489.50 $   Plus shipping costs $45.00
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Immunogen Recombinant fusion protein of full length human A20
Clone 59A426
Isotype IgG1
Purification Affinity Chromatography on Protein G
Alternative Name TNFAIP3
Background NF-kB (nuclear factor kB) regulates the expression of a large number of genes that play critical roles in apoptosis, viral replication, tumorigenesis, various autoimmune diseases and inflammation (1). The zinc finger protein A20 (2) is a tumor necrosis factor and interleukin 1 (IL- 1)-inducible protein that negatively regulates NF-kB gene expression. A20 inhibits NF-kB dependent gene expression by interfering with a novel TNF-induced and RIP- or TRAF2-mediated pathway that is different from the NIK-IkB kinase pathway (3). A20 is expressed at low levels in most organs, the highest expression levels being in lymphoid tissues. (4). Recently, it has been shown that A20 protein level is increased in lung neutrophils after (product citation 1).
UniProt P21580
Research Area Cancer, Growth Factors, Innate Immunity, Cytokines
Application Notes Western blot analysis (3-5ug/ml, positive control: Daudi). In Daudi, a ~70 kDa band is observed. Immunoprecipitation: 1 - 2 ug/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% Sodium Azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Opipari, Boguski, Dixit: "The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein." in: The Journal of biological chemistry, Vol. 265, Issue 25, pp. 14705-8, 1990 (PubMed).

Heyninck, De Valck, Vanden Berghe et al.: "The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN." in: The Journal of cell biology, Vol. 145, Issue 7, pp. 1471-82, 1999 (PubMed).

Alternatives for antigen "Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3)", type "Antibodies"
Hosts (41), (7), (3), (1)
Reactivities (52), (30), (30), (12), (12), (12), (1)
Applications (38), (23), (17), (11), (10), (4), (2), (2), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (4), (4), (1), (1), (1), (1)