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Details for Product No. ABIN121209

V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma) (AKT3) (AA 119-136) antibody

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Antigen
Synonyms AI851531, D930002M15Rik, Nmf350, Pkbg, MPPH, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2
Epitope
»Alternatives AA 119-136
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN121209
Quantity 0.1 mg
Price
445.50 $   Plus shipping costs $45.00
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Availability Discontinued
Immunogen Synthetic peptide corresponding to amino acid residues 119-136 of human AKT3. AA Sequence:CSPTSQIDNIGEEEMDAS
Clone 66C1247
Isotype IgG1
Purification Protein G Chromatography
Alternative Name AKT3 / PKB gamma
Background AKT, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activat phosphtidylinositol 3-kinase (PI 3-kinase). The major activity of AKT/PKB is to mediate cell survival. AKT/PKB is also believed to be a critical factor in the genesis of cancer as the tumor suppressor PTEN was found to antagonise PI-3 kinase and AKT/PKB kinase activity. There are 3 known isoforms of this enzyme in mammalian cells (1/alpha, 2/beta and 3/gamma). AKT1, 2 and 3 contain a key regulatory serine phosphorylation site in the carboxy- terminal region of the protein. AKT/PKB phosphorylation is critical for it activity.
UniProt Q9Y243
Research Area Signaling
Application Notes Western blotting (1-2 ug/ml). Recommended Positive Control: human kidney. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% Sodium Azide as preservative and 0.05% BSA as stabilizer.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Alessi, Andjelkovic, Caudwell et al.: "Mechanism of activation of protein kinase B by insulin and IGF-1." in: The EMBO journal, Vol. 15, Issue 23, pp. 6541-51, 1997 (PubMed).

Franke, Kaplan, Cantley: "PI3K: downstream AKTion blocks apoptosis." in: Cell, Vol. 88, Issue 4, pp. 435-7, 1997 (PubMed).

Cantley, Neel: "New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 8, pp. 4240-5, 1999 (PubMed).

Kandel, Hay: "The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB." in: Experimental cell research, Vol. 253, Issue 1, pp. 210-29, 1999 (PubMed).

Alternatives for antigen "V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma) (AKT3)", type "Antibodies"
Hosts (88), (42), (10), (3)
Reactivities (142), (70), (57), (37), (34), (20), (17), (1), (1), (1)
Applications (107), (70), (31), (29), (20), (18), (5), (4), (4), (2), (2), (1), (1), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (21), (15), (8), (8), (5), (4), (4), (3), (2), (1), (1), (1), (1)
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