anti-AKT3 antibody (V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma)) (AA 119-136)

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AA 119-136
(35), (33), (19), (17), (15), (12), (11), (10), (9), (8), (8), (6), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(229), (65), (44), (6), (5), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
(149), (56), (21), (3)
Clonality (Clone)
Monoclonal ()
This AKT3 antibody is un-conjugated
(9), (9), (7), (7), (7), (7), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(174), (128), (54), (31), (18), (12), (12), (8), (7), (6), (4), (2), (2), (1), (1)
Pubmed 4 references available
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Quantity 0.1 mg
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Immunogen Synthetic peptide corresponding to amino acid residues 119-136 of human AKT3. AA Sequence:CSPTSQIDNIGEEEMDAS
Clone 66C1247
Isotype IgG1
Purification Protein G Chromatography
Alternative Name AKT3 / PKB gamma (AKT3 Antibody Abstract)
Background AKT, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activat phosphtidylinositol 3-kinase (PI 3-kinase). The major activity of AKT/PKB is to mediate cell survival. AKT/PKB is also believed to be a critical factor in the genesis of cancer as the tumor suppressor PTEN was found to antagonise PI-3 kinase and AKT/PKB kinase activity. There are 3 known isoforms of this enzyme in mammalian cells (1/alpha, 2/beta and 3/gamma). AKT1, 2 and 3 contain a key regulatory serine phosphorylation site in the carboxy- terminal region of the protein. AKT/PKB phosphorylation is critical for it activity.
UniProt Q9Y243
Research Area Signaling
Pathways PI3K-Akt Signaling, RTK Signaling, TLR Signaling
Application Notes Western blotting (1-2 ug/ml). Recommended Positive Control: human kidney. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% Sodium Azide as preservative and 0.05% BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-AKT3 antibody (V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma)) (AA 119-136) (ABIN121209) Western blot analysis for AKT3 using ABIN121209 at 2 ug/ml dilution against 30 ug/lan...
General Kandel, Hay: "The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB." in: Experimental cell research, Vol. 253, Issue 1, pp. 210-29, 1999 (PubMed).

Cantley, Neel: "New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 8, pp. 4240-5, 1999 (PubMed).

Franke, Kaplan, Cantley: "PI3K: downstream AKTion blocks apoptosis." in: Cell, Vol. 88, Issue 4, pp. 435-7, 1997 (PubMed).

Alessi, Andjelkovic, Caudwell et al.: "Mechanism of activation of protein kinase B by insulin and IGF-1." in: The EMBO journal, Vol. 15, Issue 23, pp. 6541-51, 1997 (PubMed).

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