Lethal Factor (LEF) (AA 779-792) antibody

Details for Product No. ABIN121211
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Antigen
Epitope
AA 779-792
(3), (1), (1)
Reactivity
Bacillus anthracis
(24)
Host
Mouse
(18), (6)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(12), (10), (7), (4), (3)
Pubmed 1 reference available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN121211
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Immunogen Synthetic peptide corresponding to amino acids 779-792 of the Anthrax LF protein (~90 kD)
Clone 5F502-2
Isotype IgG1
Purification Protein G Chromatography.
Alternative Name Lethal Factor (LF)
Background Anthrax PA (Protective Antigen) and Anthrax LF (Lethal Factor), along with Anthrax EF (Edema Factor), are toxins produced by Bacillus anthracis. All three of the proteins must be present for toxicity to occur. It begins with the binding of PA to its cell-surface receptor, ATR (Anthrax Toxin Receptor), at which point PA is cleaved and the resulting 63 kD carboxyl-terminal fragment binds to LF and EF. LF is a protease that is known to cleave members of the mitogen-activated protein kinase kinase (MAPKK) family2.
UniProt P15917
Application Notes Western blot analysis (0.1 ug/ml, positive control: recombinant protein). In Daudi, a ~70 kDa band is observed. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA as stabilizer and 0.05% Sodium Azide as preserative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Lethal Factor (LEF) (AA 779-792) antibody Western blot analysis of Anthrax LF in recombinant protein using ABIN121211 at 0.1 ug/ml.
General Collier, Young: "Anthrax toxin." in: Annual review of cell and developmental biology, Vol. 19, pp. 45-70, 2003 (PubMed).

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