Activating Transcription Factor 2 (ATF2) (pThr71), (pThr53) antibody

Details for Product No. ABIN121212
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Antigen
Epitope
pThr71, pThr53
(62), (50), (48), (44), (37), (34), (33), (33), (27), (25), (24), (24), (21), (20), (20), (16), (15), (11), (9), (9), (8), (8), (7), (7), (7), (6), (5), (5), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(571), (366), (351), (88), (65), (50), (49), (12), (3), (1), (1), (1), (1), (1)
Host
Mouse
(535), (22), (9), (8)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(16), (16), (16), (14), (14), (14), (14), (14), (14), (14), (14), (2), (2), (2)
Application
Western Blotting (WB)
(365), (236), (150), (140), (111), (103), (79), (34), (17), (11), (10), (10), (6), (3), (3), (2), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN121212
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Immunogen This antibody was generated by immunizing mice with a synthetic peptide containing phosphorylated threonine at position 71 of human ATF-2.
Clone 103C411-2
Isotype IgG1
Purification Protein G Chromatography
Alternative Name ATF2
Background ATF-2 is a member of the group of bZip transcription factors. Heterodimer formation between members of the bZip group is common and is believed to add diversity to the cis-acting elements at which binding of the dimers is directed. Specifically, ATF-2 may dimerize with c-Jun, as occurs in response to E1a, and in so doing shift the binding preference of c-Jun toward ATF/CRE sites (1-3). Deletion analysis has indicated that the N-terminal region of ATF-2 containing threonine at residues 69 and 71 are essential for this purpose. These threonine residues are phosphorylated by JNK/SAPK for transcriptional activation.
UniProt P15336
Research Area Immunology, Innate Immunity, Transcription Factors
Application Notes Western blot: 2 ug/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.2% Gelatin and 0.05% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Shelf Life: 6 month from despatch.
Expiry Date 6 months
Supplier Images
anti-Activating Transcription Factor 2 (ATF2) (pThr71), (pThr53) antibody Detection of ATF-2 phosphorylation in HeLa cell lysate with anti-phospho ATF-2 mAb (Cat. # ABIN123279). Lane A. Untreated cell lysate, Lane B. HeLa cells treated with TNF for 1 hr
General Hai, Curran: "Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 9, pp. 3720-4, 1991 (PubMed).

Benbrook, Jones: "Heterodimer formation between CREB and JUN proteins." in: Oncogene, Vol. 5, Issue 3, pp. 295-302, 1990 (PubMed).

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