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Details for Product No. ABIN121212

Activating Transcription Factor 2 (ATF2) (pThr71), (pThr53) antibody

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Antigen
Synonyms CRE-BP1, CREB2, HB16, TREB7, Atf-2, CRE-BP, Creb2, D130078H02Rik, D18875, Tg(Gzma-Klra1)7Wum, mXBP, atf2-A, atf2l, CHN1, CG12850, CG3749, dATF-2, DmelCG30420, CG30420
Epitope
»Alternatives pThr71, pThr53
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN121212
Quantity 0.1 mg
Price
500.50 $   Plus shipping costs $45.00
Shipping to
Availability Discontinued
Immunogen This antibody was generated by immunizing mice with a synthetic peptide containing phosphorylated threonine at position 71 of human ATF-2.
Clone 103C411-2
Isotype IgG1
Purification Protein G Chromatography
Alternative Name ATF2
Background ATF-2 is a member of the group of bZip transcription factors. Heterodimer formation between members of the bZip group is common and is believed to add diversity to the cis-acting elements at which binding of the dimers is directed. Specifically, ATF-2 may dimerize with c-Jun, as occurs in response to E1a, and in so doing shift the binding preference of c-Jun toward ATF/CRE sites (1-3). Deletion analysis has indicated that the N-terminal region of ATF-2 containing threonine at residues 69 and 71 are essential for this purpose. These threonine residues are phosphorylated by JNK/SAPK for transcriptional activation.
UniProt P15336
Research Area Immunology, Innate Immunity, Transcription Factors
Application Notes Western blot: 2 ug/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.2% Gelatin and 0.05% Sodium Azide
Preservative Sodium azide
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Shelf Life: 6 month from despatch.
Expiry Date 6 months
Hai, Curran: "Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 9, pp. 3720-4, 1991 (PubMed).

Benbrook, Jones: "Heterodimer formation between CREB and JUN proteins." in: Oncogene, Vol. 5, Issue 3, pp. 295-302, 1990 (PubMed).

Alternatives for antigen "Activating Transcription Factor 2 (ATF2)", type "Antibodies"
Hosts (473), (24), (9), (9)
Reactivities (508), (347), (330), (111), (89), (72), (62), (12), (2), (1), (1), (1), (1), (1)
Applications (290), (161), (160), (153), (132), (86), (50), (13), (11), (11), (3), (3), (2), (1), (1), (1), (1), (1)
Conjugates (16), (16), (16), (16), (16), (16), (16), (16), (16), (16), (16)
Epitopes (63), (59), (50), (44), (31), (29), (28), (28), (21), (20), (20), (18), (17), (17), (17), (16), (11), (9), (7), (5), (4), (4), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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