Caspase 14, Apoptosis-Related Cysteine Peptidase (CASP14) (AA 2-18) antibody

Details for Product No. ABIN121216
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Antigen
Epitope
AA 2-18
(20), (14), (9), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(84), (40), (37), (12), (1), (1)
Host
Mouse
(74), (14), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(6), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Flow Cytometry (FACS)
(50), (32), (23), (19), (14), (11), (11), (10), (5), (3)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN121216
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Immunogen Synthetic peptide corresponding to amino acids 2-18 of mouse caspase-14
Clone 70A1426
Isotype IgG
Purification Protein G affinity chromatography
Alternative Name Caspase-14
Background Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a2b2 tetramer to form the active enzyme. Caspase-14 is a newly identified member of Caspase family. It has conserved active site pentapeptide, QACRG. However, no proteolytic or biological activities have been identified so far. It's high expression in embryonic tissues and limited expression in adult tissues suggests that it may have some role during ontogenesis.
UniProt O89094
Research Area Apoptosis/Necrosis, Autophagy
Application Notes Western blotting (2-4 ug/ml): in mouse spleen, a 30 kDa band is observed. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Caspase 14, Apoptosis-Related Cysteine Peptidase (CASP14) (AA 2-18) antibody Western blot analysis for Caspase-14 using ABIN121216 at 2 ug/ml dilution against 10 ug of mouse spleen cell lysate
General Cohen: "Caspases: the executioners of apoptosis." in: The Biochemical journal, Vol. 326 ( Pt 1), Issue 5693, pp. 1-16, 1997 (PubMed).

Hu, Snipas, Vincenz et al.: "Caspase-14 is a novel developmentally regulated protease." in: The Journal of biological chemistry, Vol. 273, Issue 45, pp. 29648-53, 1998 (PubMed).

Ahmad, Srinivasula, Hegde et al.: "Identification and characterization of murine caspase-14, a new member of the caspase family." in: Cancer research, Vol. 58, Issue 22, pp. 5201-5, 1998 (PubMed).

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