Interleukin 17 Receptor B (IL17RB) antibody

Details for Product No. ABIN121258
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Antigen
Synonyms CRL4, EVI27, IL17BR, IL17RH1, Evi27, Il17br, IL-17ER, IL-17Rh1, IL17RB
Reactivity
Human
(33), (21), (20), (17), (17), (17)
Host
Mouse
(32), (6), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(21), (14), (11), (9), (6), (4), (2), (2), (2), (1)
Pubmed 6 references available
Catalog no. ABIN121258
Quantity 0.1 mg
Price
456.50 $   Plus shipping costs $45.00
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Immunogen Recombinant protein of human IL-17BR
Clone 97C691
Isotype IgG1
Purification Protein G Chromatography
Alternative Name IL17RB / IL17BR
Background Recently, a number of cytokines belonging to the interleukin (IL)-17 family have been identified. These are termed as IL-17B, IL-17C (1) and IL-17E (2). IL-17 is a potent proinflammatory cytokine that plays roles in a number of diseases including rheumatoid arthritis (3), multiple sclerosis (4), and promotion of tumor growth (5). IL-17B, C, and E like IL-17 are able to induce proinflammatory responses. However, they do not bind to the IL-17 receptor suggesting that additional IL-17R related receptor might exist. Receptor for IL-17B and IL-17E has been independently isolated by Shi, et al (6) and Lee, et al. (2) and has been designated as EV127 (in mouse) and IL-17Rh1 (in human), respectively. IL-17E induces activation of NF-kB pathway and like IL-17 also induces production of IL-8. IL-17Rh1 mRNA is highly expressed in Kidney and liver and at moderate level in small intestine, colon, and brain (2).
UniProt Q9NRM6
Application Notes Western blot analysis (2.0 ug/ml, positive control: HeLa, a 45 kDa band is observed). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Interleukin 17 Receptor B (IL17RB) antibody Western blot analysis of IL-17BR HeLa cell lysate using ABIN121258 (Lane 1: 1 ug/ml, lane 2: 2 ug/ml of antibody).
General Shalom-Barak, Quach, Lotz: "Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB." in: The Journal of biological chemistry, Vol. 273, Issue 42, pp. 27467-73, 1998 (PubMed).

Matusevicius, Kivisaekk, He et al.: "Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis." in: Multiple sclerosis (Houndmills, Basingstoke, England), Vol. 5, Issue 2, pp. 101-4, 1999 (PubMed).

Tartour, Fossiez, Joyeux et al.: "Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice." in: Cancer research, Vol. 59, Issue 15, pp. 3698-704, 1999 (PubMed).

Li, Chen, Huang et al.: "Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 2, pp. 773-8, 2000 (PubMed).

Shi, Ullrich, Zhang et al.: "A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity." in: The Journal of biological chemistry, Vol. 275, Issue 25, pp. 19167-76, 2000 (PubMed).

Lee, Ho, Maruoka et al.: "IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1." in: The Journal of biological chemistry, Vol. 276, Issue 2, pp. 1660-4, 2001 (PubMed).

Hosts (32), (6), (1)
Reactivities (33), (21), (20), (17), (17), (17)
Applications (21), (14), (11), (9), (6), (4), (2), (2), (2), (1)
Conjugates (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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