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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Interleukin 17 Receptor B (IL17RB) antibody
|Synonyms||CRL4, EVI27, IL17BR, IL17RH1, MGC5245, Evi27, Il17br, IL-17ER, IL-17Rh1, IL17RB, MGC148783|
Alternatives Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
|6 references available|
|Quantity||0.1 mg (0.5 mg/ml)|
|Price||352.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 6 to 8 Business Days|
|Alternative name||IL17RB / IL17BR|
|Immunogen||Recombinant protein of human IL-17BR|
|Description||Recently, a number of cytokines belonging to the interleukin (IL)-17 family have been identified. These are termed as IL-17B, IL-17C (1) and IL-17E (2). IL-17 is a potent proinflammatory cytokine that plays roles in a number of diseases including rheumatoid arthritis (3), multiple sclerosis (4), and promotion of tumor growth (5). IL-17B, C, and E like IL-17 are able to induce proinflammatory responses. However, they do not bind to the IL-17 receptor suggesting that additional IL-17R related receptor might exist. Receptor for IL-17B and IL-17E has been independently isolated by Shi, et al (6) and Lee, et al. (2) and has been designated as EV127 (in mouse) and IL-17Rh1 (in human), respectively. IL-17E induces activation of NF-kB pathway and like IL-17 also induces production of IL-8. IL-17Rh1 mRNA is highly expressed in Kidney and liver and at moderate level in small intestine, colon, and brain (2).|
|Application Notes||Western blot analysis (2.0 ug/ml, positive control: HeLa, a 45 kDa band is observed). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.|
|Buffer||PBS containing 0.2 % gelatin and 0.05 % sodium azide|
|Storage||Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.|
|Restrictions||For Research Use only|
|Western blot analysis of IL-17BR HeLa cell lysate using ABIN121258 (Lane 1: 1 ug/ml, lane 2: 2 ug/ml of antibody).|
Shalom-Barak, Quach, Lotz: "Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB." in: The Journal of biological chemistry, Vol. 273, Issue 42, pp. 27467-73, 1998 (PubMed).
Matusevicius, Kivisaekk, He et al.: "Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis." in: Multiple sclerosis (Houndmills, Basingstoke, England), Vol. 5, Issue 2, pp. 101-4, 1999 (PubMed).
Tartour, Fossiez, Joyeux et al.: "Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice." in: Cancer research, Vol. 59, Issue 15, pp. 3698-704, 1999 (PubMed).
Li, Chen, Huang et al.: "Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 2, pp. 773-8, 2000 (PubMed).
Shi, Ullrich, Zhang et al.: "A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity." in: The Journal of biological chemistry, Vol. 275, Issue 25, pp. 19167-76, 2000 (PubMed).
Lee, Ho, Maruoka et al.: "IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1." in: The Journal of biological chemistry, Vol. 276, Issue 2, pp. 1660-4, 2001 (PubMed).
|Hosts||Rabbit (30), Mouse (2), Rat (1)|
|Reactivities||Human (29), Mouse (Murine) (21), Rat (Rattus) (20), Cow (Bovine) (19), Dog (Canine) (19), Horse (Equine) (18), Pig (Porcine) (18), Cat (Feline) (1), Chicken (1)|
|Applications||Immunofluorescence (IF) (17), Flow Cytometry (FACS) (16), Western Blotting (WB) (15), ELISA (11), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (IHC) (3), Immunoprecipitation (IP) (2), Immunoelectron Microscopy (IEM) (1)|
|Conjugates||Biotin (2), FITC (2), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|
|Epitopes||AA 102-118 (1), Center (1), Extracellular Domain (1)|